| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  SHP394 | 1; SHP394 | IC50 | = | 0.023 | uM | ALA4414023 | 7.64 | nM | Homo sapiens | ||
| 2. | SHP394 | 1; SHP394 | IC50 | = | 0.018 | uM | ALA4414022 | 7.75 | nM | Homo sapiens | ||
| 3. | SHP394 | 1; SHP394 | Activity | = | 2.2 | % | ALA4414052 | % | ||||
| 4. | SHP394 | 1; SHP394 | t1/2 | = | 10.9 | hr | ALA4414051 | hr | ||||
| 5. | SHP394 | 1; SHP394 | CL | = | 21 | microL/min/mg | ALA4414050 | mL.min-1.g-1 | ||||
| 6. | SHP394 | 1; SHP394 | Activity | = | 34 | % | ALA4414046 | % | Homo sapiens | |||
| 7. | SHP394 | 1; SHP394 | T/C | = | 11 | % | ALA4414045 | % | Homo sapiens | |||
| 8. | SHP394 | 1; SHP394 | Activity | 0 | ALA4414044 | Dose-dependent effect | Homo sapiens | |||||
| 9. | SHP394 | 1; SHP394 | INH | 0 | ALA4414043 | Dose-dependent effect | % | Mus musculus | ||||
| 10. | SHP394 | 1; SHP394 | Drug uptake | 0 | ALA4414042 | Dose-dependent effect | ||||||
| 11. | SHP394 | 1; SHP394 | IC50 | = | 1.38 | uM | ALA4414041 | 5.86 | nM | Homo sapiens | ||
| 12. | SHP394 | 1; SHP394 | Ratio | = | 15 | ALA4414040 | ||||||
| 13. | SHP394 | 1; SHP394 | solubility | = | 0.98 | mM | ALA4414039 | nM | ||||
| 14. | SHP394 | 1; SHP394 | t1/2 | > | 2 | hr | ALA4414038 | hr | ||||
| 15. | SHP394 | 1; SHP394 | CLH | = | 7.9 | microL/min/mg | ALA4414037 | mL.min-1.g-1 | ||||
| 16. | SHP394 | 1; SHP394 | F | = | 29 | % | ALA4414031 | % | ||||
| 17. | SHP394 | 1; SHP394 | AUC/dose | = | 0.45 | uM.hr | ALA4414030 | uM.hr | ||||
| 18. | SHP394 | 1; SHP394 | t1/2 | > | 2 | hr | ALA4414029 | hr | ||||
| 19. | SHP394 | 1; SHP394 | CLH | = | 7.9 | microL/min/mg | ALA4414028 | mL.min-1.g-1 | ||||
| 20. | SHP394 | 1; SHP394 | Papp | = | 1.02 | 10'-6 cm/s | ALA4414027 | 10'-6 cm/s |
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