Activities

#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide	24	Activity		0		ALA4361980		Active		Rattus norvegicus
2.	4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide	24	Activity		0		ALA4361979		Active		Rattus norvegicus
3.	4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide	24	Activity		0		ALA4361978		Active		Rattus norvegicus
4.	4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide	24	Activity		0		ALA4361977		Active		Rattus norvegicus
5.	4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide	24	Activity		0		ALA4361976		Active		Rattus norvegicus
6.	4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide	24	Time	=	24	hr	ALA4361975			hr
7.	4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide	24	Ratio	=	63		ALA4361974
8.	4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide	24	Cp	=	632	nM	ALA4361973			nM
9.	4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide	24	INH	<	5	%	ALA4361972			%	Homo sapiens
10.	4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide	24	Activity	<	5	%	ALA4361971			%	Homo sapiens
11.	4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide	24	t1/2	=	92	min	ALA4361969			hr
12.	4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide	24	IC50	=	9	nM	ALA4361968	8.05		nM	Rattus norvegicus
13.	4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide	24	IC50	=	10	nM	ALA4361967	8.00		nM	Rattus norvegicus
14.	4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide	24	Time	=	24	hr	ALA4361966			hr
15.	4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide	24	Ratio IC50	=	8		ALA4361965				Homo sapiens
16.	4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide	24	IC50	=	48.4	nM	ALA4361964	7.32		nM	Homo sapiens
17.	4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide	24	Ratio IC50	=	6000		ALA4361963
18.	4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide	24	Activity		0		ALA4361962		Non-Toxic		Homo sapiens
19.	4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide	24	solubility	>	200	uM	ALA4361961			nM
20.	4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide	24	t1/2	=	61	min	ALA4361960			hr

1.

4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide

24

Activity

0

ALA4361980

Active

Rattus norvegicus

2.

4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide

24

Activity

0

ALA4361979

Active

Rattus norvegicus

3.

4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide

24

Activity

0

ALA4361978

Active

Rattus norvegicus

4.

4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide

24

Activity

0

ALA4361977

Active

Rattus norvegicus

5.

4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide

24

Activity

0

ALA4361976

Active

Rattus norvegicus

6.

4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide

24

Time

=

24

hr

ALA4361975

hr

7.

4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide

24

Ratio

=

63

ALA4361974

8.

4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide

24

Cp

=

632

nM

ALA4361973

nM

9.

4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide

24

INH

<

5

%

ALA4361972

%

Homo sapiens

10.

4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide

24

Activity

<

5

%

ALA4361971

%

Homo sapiens

11.

4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide

24

t1/2

=

92

min

ALA4361969

hr

12.

4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide

24

IC50

=

9

nM

ALA4361968

8.05

nM

Rattus norvegicus

13.

4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide

24

IC50

=

10

nM

ALA4361967

8.00

nM

Rattus norvegicus

14.

4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide

24

Time

=

24

hr

ALA4361966

hr

15.

4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide

24

Ratio IC50

=

8

ALA4361965

Homo sapiens

16.

4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide

24

IC50

=

48.4

nM

ALA4361964

7.32

nM

Homo sapiens

17.

4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide

24

Ratio IC50

=

6000

ALA4361963

18.

4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide

24

Activity

0

ALA4361962

Non-Toxic

Homo sapiens

19.

4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide

24

solubility

>

200

uM

ALA4361961

nM

20.

4-Fluoro-N-(2-(5-(2,4,5-trifluoro-3-hydroxybenzoyl)thiophen-2-yl)phenyl)benzene-sulfonamide

24

t1/2

=

61

min

ALA4361960

hr