Activities

#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Assay	Assay Organism
1.	2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide	14	RatioGI50	=	1.4		ALA4351181			Homo sapiens
2.	2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide	14	EC50	=	2.69	uM	ALA4351182	5.57	nM	Homo sapiens
3.	2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide	14	EC50	=	0.728	uM	ALA4351183	6.14	nM	Homo sapiens
4.	2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide	14	INH	>=	20	%	ALA4351184		%	Homo sapiens
5.	2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide	14	IC50	=	1.73	uM	ALA4351185	5.76	nM	Homo sapiens
6.	2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide	14	INH	>=	20	%	ALA4351186		%	Homo sapiens
7.	2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide	14	IC50	=	2.38	uM	ALA4351187	5.62	nM	Homo sapiens
8.	2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide	14	GI50	=	0.466	uM	ALA4351188		nM	Homo sapiens
9.	2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide	14	GI50	=	0.292	uM	ALA4351189		nM	Homo sapiens
10.	2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide	14	GI50	=	0.09	uM	ALA4351190		nM	Homo sapiens
11.	2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide	14	GI50	=	0.059	uM	ALA4351191		nM	Homo sapiens
12.	2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide	14	RatioGI50	=	32		ALA4351192			Homo sapiens
13.	2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide	14	RatioGI50	=	20		ALA4351193			Homo sapiens
14.	2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide	14	RatioGI50	=	6.3		ALA4351194			Homo sapiens
15.	2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide	14	RatioGI50	=	4.1		ALA4351195			Homo sapiens
16.	2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide	14	GI50	=	2.88	uM	ALA4351196		nM	Homo sapiens
17.	2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide	14	GI50	=	1.74	uM	ALA4351197		nM	Homo sapiens
18.	2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide	14	GI50	=	0.376	uM	ALA4351198		nM	Homo sapiens
19.	2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide	14	GI50	=	0.189	uM	ALA4351199		nM	Homo sapiens
20.	2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide	14	RatioGI50	=	7.1		ALA4351200			Homo sapiens

1.

2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide

14

RatioGI50

=

1.4

ALA4351181

Homo sapiens

2.

2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide

14

EC50

=

2.69

uM

ALA4351182

5.57

nM

Homo sapiens

3.

2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide

14

EC50

=

0.728

uM

ALA4351183

6.14

nM

Homo sapiens

4.

2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide

14

INH

>=

20

%

ALA4351184

%

Homo sapiens

5.

2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide

14

IC50

=

1.73

uM

ALA4351185

5.76

nM

Homo sapiens

6.

2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide

14

INH

>=

20

%

ALA4351186

%

Homo sapiens

7.

2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide

14

IC50

=

2.38

uM

ALA4351187

5.62

nM

Homo sapiens

8.

2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide

14

GI50

=

0.466

uM

ALA4351188

nM

Homo sapiens

9.

2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide

14

GI50

=

0.292

uM

ALA4351189

nM

Homo sapiens

10.

2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide

14

GI50

=

0.09

uM

ALA4351190

nM

Homo sapiens

11.

2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide

14

GI50

=

0.059

uM

ALA4351191

nM

Homo sapiens

12.

2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide

14

RatioGI50

=

32

ALA4351192

Homo sapiens

13.

2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide

14

RatioGI50

=

20

ALA4351193

Homo sapiens

14.

2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide

14

RatioGI50

=

6.3

ALA4351194

Homo sapiens

15.

2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide

14

RatioGI50

=

4.1

ALA4351195

Homo sapiens

16.

2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide

14

GI50

=

2.88

uM

ALA4351196

nM

Homo sapiens

17.

2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide

14

GI50

=

1.74

uM

ALA4351197

nM

Homo sapiens

18.

2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide

14

GI50

=

0.376

uM

ALA4351198

nM

Homo sapiens

19.

2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide

14

GI50

=

0.189

uM

ALA4351199

nM

Homo sapiens

20.

2-[4-(7-methyl-2-pyridin-3-yl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-yl)piperazin-1-yl]-2-phenylacetamide

14

RatioGI50

=

7.1

ALA4351200

Homo sapiens