# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA4545044 | 46; PF-06659286 | Activity | 0 | ALA4351584 | Toxic | ||||||
2. | ALA4545044 | 46; PF-06659286 | Activity | 0 | ALA4351582 | Non-Toxic | ||||||
3. | ALA4545044 | 46; PF-06659286 | Activity | 0 | ALA4351581 | Non-Toxic | ||||||
4. | ALA4545044 | 46; PF-06659286 | IC50 | = | 159.7 | uM | ALA4351580 | nM | ||||
5. | ALA4545044 | 46; PF-06659286 | IC50 | > | 100 | uM | ALA4351579 | nM | Homo sapiens | |||
6. | ALA4545044 | 46; PF-06659286 | IC50 | > | 30 | uM | ALA4351578 | nM | Homo sapiens | |||
7. | ALA4545044 | 46; PF-06659286 | IC50 | = | 6.6 | uM | ALA4351577 | 5.18 | nM | Homo sapiens | ||
8. | ALA4545044 | 46; PF-06659286 | IC50 | = | 8.7 | uM | ALA4351576 | 5.06 | nM | Homo sapiens | ||
9. | ALA4545044 | 46; PF-06659286 | Activity | 0 | ALA4351570 | Active | Mus musculus | |||||
10. | ALA4545044 | 46; PF-06659286 | Activity | 0 | ALA4351568 | Active | Rattus norvegicus | |||||
11. | ALA4545044 | 46; PF-06659286 | Occ50 | = | 34.4 | ng/g | ALA4351562 | ng/g | Rattus norvegicus | |||
12. | ALA4545044 | 46; PF-06659286 | Occ50 | = | 18.4 | ng/g | ALA4351561 | ng/g | Rattus norvegicus | |||
13. | ALA4545044 | 46; PF-06659286 | Occ50 | = | 74.4 | ng/g | ALA4351560 | ng/g | Rattus norvegicus | |||
14. | ALA4545044 | 46; PF-06659286 | Occ50 | = | 35.8 | ng/g | ALA4351558 | ng/g | Rattus norvegicus | |||
15. | ALA4545044 | 46; PF-06659286 | Occ50 | = | 513.1 | ng/ml | ALA4351559 | ng/ml | Rattus norvegicus | |||
16. | ALA4545044 | 46; PF-06659286 | F | = | 43 | % | ALA4351557 | % | ||||
17. | ALA4545044 | 46; PF-06659286 | Vdss | = | 2.61 | L/Kg | ALA4351556 | L.kg-1 | ||||
18. | ALA4545044 | 46; PF-06659286 | beta t1/2 | = | 0.75 | hr | ALA4351555 | hr | ||||
19. | ALA4545044 | 46; PF-06659286 | CL | = | 33 | ml/min.kg | ALA4351554 | mL.min-1.kg-1 | ||||
20. | ALA4545044 | 46; PF-06659286 | F | = | 76 | % | ALA4351553 | % |