Activities

#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide	21b	Activity		0		ALA4381548		Dose-dependent effect		Rattus norvegicus
2.	3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide	21b	IC50	=	3.37	uM	ALA4381549	5.47		nM	Homo sapiens
3.	3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide	21b	Activity	=	33	%	ALA4381547			%	Rattus norvegicus
4.	3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide	21b	Activity	=	27	%	ALA4381546			%	Rattus norvegicus
5.	3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide	21b	Activity		0		ALA4381545		Active		Rattus norvegicus
6.	3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide	21b	Activity		0		ALA4381544		Active		Rattus norvegicus
7.	3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide	21b	Activity		0		ALA4381543		Active		Rattus norvegicus
8.	3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide	21b	Activity		0		ALA4381542		Active		Rattus norvegicus
9.	3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide	21b	Activity		0		ALA4381537		Dose-dependent effect		Rattus norvegicus
10.	3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide	21b	IC50	=	161	uM	ALA4381536			nM	Mus musculus
11.	3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide	21b	BPR	=	9.55		ALA4381535
12.	3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide	21b	BPR	=	6.49		ALA4381534
13.	3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide	21b	BPR	=	2.94		ALA4381533
14.	3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide	21b	Cp	=	144	ng/ml	ALA4381532			ng/ml
15.	3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide	21b	Cp	=	762	ng/ml	ALA4381531			ng/ml
16.	3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide	21b	Cp	=	709	ng/ml	ALA4381530			ng/ml
17.	3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide	21b	Drug uptake	=	1298	ng/g	ALA4381529			ng/g
18.	3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide	21b	Drug uptake	=	4756	ng/g	ALA4381528			ng/g
19.	3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide	21b	Drug uptake	=	2122	ng/g	ALA4381527			ng/g
20.	3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide	21b	Drug uptake		0		ALA4381526		Active

1.

3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide

21b

Activity

0

ALA4381548

Dose-dependent effect

Rattus norvegicus

2.

3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide

21b

IC50

=

3.37

uM

ALA4381549

5.47

nM

Homo sapiens

3.

3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide

21b

Activity

=

33

%

ALA4381547

%

Rattus norvegicus

4.

3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide

21b

Activity

=

27

%

ALA4381546

%

Rattus norvegicus

5.

3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide

21b

Activity

0

ALA4381545

Active

Rattus norvegicus

6.

3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide

21b

Activity

0

ALA4381544

Active

Rattus norvegicus

7.

3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide

21b

Activity

0

ALA4381543

Active

Rattus norvegicus

8.

3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide

21b

Activity

0

ALA4381542

Active

Rattus norvegicus

9.

3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide

21b

Activity

0

ALA4381537

Dose-dependent effect

Rattus norvegicus

10.

3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide

21b

IC50

=

161

uM

ALA4381536

nM

Mus musculus

11.

3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide

21b

BPR

=

9.55

ALA4381535

12.

3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide

21b

BPR

=

6.49

ALA4381534

13.

3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide

21b

BPR

=

2.94

ALA4381533

14.

3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide

21b

Cp

=

144

ng/ml

ALA4381532

ng/ml

15.

3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide

21b

Cp

=

762

ng/ml

ALA4381531

ng/ml

16.

3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide

21b

Cp

=

709

ng/ml

ALA4381530

ng/ml

17.

3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide

21b

Drug uptake

=

1298

ng/g

ALA4381529

ng/g

18.

3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide

21b

Drug uptake

=

4756

ng/g

ALA4381528

ng/g

19.

3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide

21b

Drug uptake

=

2122

ng/g

ALA4381527

ng/g

20.

3-((4'-Chloro-[1,1'-biphenyl]-4-yl)methoxy)-N-hydroxyisoxazole-5-carboxamide

21b

Drug uptake

0

ALA4381526

Active