| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA4562467 | 5f; Table 1, Entry 8, Table 2, Entry 2 | INH | = | 24 | % | ALA4374650 | % | Homo sapiens | |||
| 2. | ALA4562467 | 5f; Table 1, Entry 8, Table 2, Entry 2 | IC50 | > | 100 | uM | ALA4374649 | nM | Homo sapiens | |||
| 3. | ALA4562467 | 5f; Table 1, Entry 8, Table 2, Entry 2 | Activity | 0 | ALA4374648 | Not Active | Homo sapiens | |||||
| 4. | ALA4562467 | 5f; Table 1, Entry 8, Table 2, Entry 2 | AUC | = | 1696 | ng.hr/ml | ALA4374647 | ng.hr.mL-1 | ||||
| 5. | ALA4562467 | 5f; Table 1, Entry 8, Table 2, Entry 2 | F | = | 58.5 | % | ALA4374646 | % | ||||
| 6. | ALA4562467 | 5f; Table 1, Entry 8, Table 2, Entry 2 | Cmax | = | 404 | ng/ml | ALA4374645 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | |||
| 7. | ALA4562467 | 5f; Table 1, Entry 8, Table 2, Entry 2 | Tmax | = | 1 | hr | ALA4374644 | hr | ||||
| 8. | ALA4562467 | 5f; Table 1, Entry 8, Table 2, Entry 2 | AUC | = | 289 | ng.hr/ml | ALA4374643 | ng.hr.mL-1 | ||||
| 9. | ALA4562467 | 5f; Table 1, Entry 8, Table 2, Entry 2 | Vdss | = | 4.62 | L/Kg | ALA4374642 | L.kg-1 | ||||
| 10. | ALA4562467 | 5f; Table 1, Entry 8, Table 2, Entry 2 | t1/2 | = | 1.14 | hr | ALA4374641 | hr | ||||
| 11. | ALA4562467 | 5f; Table 1, Entry 8, Table 2, Entry 2 | CL | = | 58 | ml/min.kg | ALA4374640 | mL.min-1.kg-1 | ||||
| 12. | ALA4562467 | 5f; Table 1, Entry 8, Table 2, Entry 2 | CLH | = | 18 | microL/min/mg | ALA4374639 | mL.min-1.g-1 | ||||
| 13. | ALA4562467 | 5f; Table 1, Entry 8, Table 2, Entry 2 | Ratio | = | 1.1 | ALA4374638 | ||||||
| 14. | ALA4562467 | 5f; Table 1, Entry 8, Table 2, Entry 2 | Papp | = | 2.8 | 10'-6 cm/s | ALA4374637 | 10'-6 cm/s | ||||
| 15. | ALA4562467 | 5f; Table 1, Entry 8, Table 2, Entry 2 | Papp | = | 2.7 | 10'-6 cm/s | ALA4374636 | 10'-6 cm/s | ||||
| 16. | ALA4562467 | 5f; Table 1, Entry 8, Table 2, Entry 2 | t1/2 | = | 64 | min | ALA4374635 | hr | ||||
| 17. | ALA4562467 | 5f; Table 1, Entry 8, Table 2, Entry 2 | CLH | = | 22 | uL/min | ALA4374634 | uL/min | ||||
| 18. | ALA4562467 | 5f; Table 1, Entry 8, Table 2, Entry 2 | t1/2 | > | 120 | min | ALA4374633 | hr | ||||
| 19. | ALA4562467 | 5f; Table 1, Entry 8, Table 2, Entry 2 | pEC50 | = | 5.11 | ALA4374632 | 5.11 | nM | Homo sapiens | |||
| 20. | ALA4562467 | 5f; Table 1, Entry 8, Table 2, Entry 2 | EC50 | = | 7.7 | uM | ALA4374632 | 5.11 | nM | Homo sapiens |
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