| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA4576800 | 10a; BR111 | Ratio IC50 | = | 15 | ALA4380986 | Homo sapiens | |||||
| 2. | ALA4576800 | 10a; BR111 | Activity | = | 30 | % | ALA4380984 | % | Homo sapiens | |||
| 3. | ALA4576800 | 10a; BR111 | EC50 | > | 100 | uM | ALA4380983 | nM | Homo sapiens | |||
| 4. | ALA4576800 | 10a; BR111 | pIC50 | = | 7.1 | ALA4380985 | 7.10 | nM | Homo sapiens | |||
| 5. | ALA4576800 | 10a; BR111 | Activity | <= | 60 | % | ALA4381005 | % | Rattus norvegicus | |||
| 6. | ALA4576800 | 10a; BR111 | Activity | = | 29 | % | ALA4381003 | % | Rattus norvegicus | |||
| 7. | ALA4576800 | 10a; BR111 | Cmax | = | 91 | ng/ml | ALA4380998 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | |||
| 8. | ALA4576800 | 10a; BR111 | Tmax | = | 210 | min | ALA4380997 | hr | ||||
| 9. | ALA4576800 | 10a; BR111 | AUC | = | 436 | ng.hr/ml | ALA4380996 | ng.hr.mL-1 | ||||
| 10. | ALA4576800 | 10a; BR111 | CL | = | 10.3 | ml/min.Kg | ALA4380995 | mL.min-1.kg-1 | ||||
| 11. | ALA4576800 | 10a; BR111 | beta t1/2 | = | 32 | min | ALA4380982 | hr | ||||
| 12. | ALA4576800 | 10a; BR111 | Vd | = | 0.4 | l | ALA4380981 | l | ||||
| 13. | ALA4576800 | 10a; BR111 | AUC | = | 811 | ng.hr/ml | ALA4380980 | ng.hr.mL-1 | ||||
| 14. | ALA4576800 | 10a; BR111 | Ratio IC50 | = | 100 | ALA4380994 | Homo sapiens | |||||
| 15. | ALA4576800 | 10a; BR111 | INH | 0 | ALA4380993 | Dose-dependent effect | % | Homo sapiens | ||||
| 16. | ALA4576800 | 10a; BR111 | pIC50 | = | 8.4 | ALA4380993 | 8.40 | nM | Homo sapiens | |||
| 17. | ALA4576800 | 10a; BR111 | IC50 | = | 4 | nM | ALA4380993 | 8.40 | nM | Homo sapiens | ||
| 18. | ALA4576800 | 10a; BR111 | Drug degradation | = | 60 | % | ALA4380992 | % | ||||
| 19. | ALA4576800 | 10a; BR111 | Stability | 0 | ALA4380989 | Stable | % | |||||
| 20. | ALA4576800 | 10a; BR111 | INH | 0 | ALA4380988 | Not Active | % | Homo sapiens |
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