| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ONO-8590580 | 40; ONO-8590580 | Occ50 | = | 1.9 | mg kg-1 | ALA4403790 | mg kg-1 | Rattus norvegicus | |||
| 2. | ONO-8590580 | 40; ONO-8590580 | Efficacy | = | -44 | % | ALA4403777 | % | Homo sapiens | |||
| 3. | ONO-8590580 | 40; ONO-8590580 | Efficacy | = | 0 | % | ALA4403776 | % | Homo sapiens | |||
| 4. | ONO-8590580 | 40; ONO-8590580 | Efficacy | = | 0 | % | ALA4403775 | % | Homo sapiens | |||
| 5. | ONO-8590580 | 40; ONO-8590580 | Efficacy | = | 0 | % | ALA4403774 | % | Homo sapiens | |||
| 6. | ONO-8590580 | 40; ONO-8590580 | Ki | = | 7.9 | nM | ALA4403720 | 8.10 | nM | Homo sapiens | ||
| 7. | ONO-8590580 | 40; ONO-8590580 | Ki | = | 24 | nM | ALA4403719 | 7.62 | nM | Homo sapiens | ||
| 8. | ONO-8590580 | 40; ONO-8590580 | Ki | = | 32 | nM | ALA4403717 | 7.50 | nM | Homo sapiens | ||
| 9. | ONO-8590580 | 40; ONO-8590580 | Ki | = | 140 | nM | ALA4403718 | 6.85 | nM | Homo sapiens | ||
| 10. | ONO-8590580 | 40; ONO-8590580 | Efficacy | = | 5 | % | ALA4701850 | % | Homo sapiens | |||
| 11. | ONO-8590580 | 40; ONO-8590580 | Activity | 0 | ALA4701847 | Non-Toxic | ||||||
| 12. | ONO-8590580 | 40; ONO-8590580 | Activity | 0 | ALA4701846 | Non-Toxic | ||||||
| 13. | ONO-8590580 | 40; ONO-8590580 | Activity | 0 | ALA4701845 | Dose-dependent effect | Rattus norvegicus | |||||
| 14. | ONO-8590580 | 40; ONO-8590580 | Activity | 0 | ALA4701844 | Dose-dependent effect | Rattus norvegicus | |||||
| 15. | ONO-8590580 | 40; ONO-8590580 | IC50 | = | 11 | uM | ALA4701843 | 4.96 | nM | Homo sapiens | ||
| 16. | ONO-8590580 | 40; ONO-8590580 | F | = | 65 | % | ALA4701842 | % | ||||
| 17. | ONO-8590580 | 40; ONO-8590580 | AUC | = | 107 | ug/ml.min | ALA4701841 | ng.hr.mL-1 | ||||
| 18. | ONO-8590580 | 40; ONO-8590580 | t1/2 | = | 131 | min | ALA4701840 | hr | ||||
| 19. | ONO-8590580 | 40; ONO-8590580 | Cmax | = | 520 | ng/ml | ALA4701839 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | |||
| 20. | ONO-8590580 | 40; ONO-8590580 | CL | = | 18 | ml/min.kg | ALA4701838 | mL.min-1.kg-1 |
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