| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA4582651 | PRALSETINIB | IC50 relative | = | 9300 | nM | ALA5303715 | Active | nM | Homo sapiens | ||
| 2. | ALA4582651 | PRALSETINIB | inhibition | = | -0.29 | % | ALA4513082 | % | Severe acute respiratory syndrome coronavirus 2 | |||
| 3. | ALA4582651 | PRALSETINIB | Inhibition | = | 11.3 | % | ALA4495582 | % | Severe acute respiratory syndrome coronavirus 2 | |||
| 4. | ALA4582651 | PRALSETINIB | inhibition | = | -0.29 | % | ALA4513082 | % | Severe acute respiratory syndrome coronavirus 2 | |||
| 5. | ALA4582651 | PRALSETINIB | Drug uptake | = | 2522 | nmol/Kg | ALA4836469 | nmol/Kg | ||||
| 6. | ALA4582651 | PRALSETINIB | Cp | = | 6315 | nM | ALA4836468 | nM | ||||
| 7. | ALA4582651 | PRALSETINIB | CLH | < | 8.6 | ml/min.kg | ALA4836467 | mL.min-1.kg-1 | ||||
| 8. | ALA4582651 | PRALSETINIB | IC50 | = | 6.5 | nM | ALA4836466 | 8.19 | nM | Homo sapiens | ||
| 9. | ALA4582651 | PRALSETINIB | IC50 | = | 2 | nM | ALA4836465 | 8.70 | nM | Homo sapiens | ||
| 10. | ALA4582651 | PRALSETINIB | Activity | 0 | ALA4836463 | Non-Toxic | ||||||
| 11. | ALA4582651 | PRALSETINIB | Activity | 0 | ALA4836461 | Active | Mus musculus | |||||
| 12. | ALA4582651 | PRALSETINIB | F | = | 77.2 | % | ALA4836460 | % | ||||
| 13. | ALA4582651 | PRALSETINIB | AUC | = | 46062 | nM.hr | ALA4836459 | standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | ng.hr.mL-1 | |||
| 14. | ALA4582651 | PRALSETINIB | Vd | = | 0.7 | L/Kg | ALA4836458 | L.kg-1 | ||||
| 15. | ALA4582651 | PRALSETINIB | CL | = | 5 | ml/kg/min | ALA4836457 | mL.min-1.kg-1 | ||||
| 16. | ALA4582651 | PRALSETINIB | CLH | < | 38 | ml/min.kg | ALA4836456 | mL.min-1.kg-1 | ||||
| 17. | ALA4582651 | PRALSETINIB | IC50 | = | 17 | nM | ALA4836455 | 7.77 | nM | Mus musculus | ||
| 18. | ALA4582651 | PRALSETINIB | IC50 | = | 0.7 | nM | ALA4836454 | 9.15 | nM | Homo sapiens | ||
| 19. | ALA4582651 | PRALSETINIB | IC50 | = | 1.93 | nM | ALA4836453 | 8.71 | nM | Homo sapiens | ||
| 20. | ALA4582651 | PRALSETINIB | IC50 | = | 0.78 | nM | ALA4836452 | 9.11 | nM | Homo sapiens |
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