| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA4593409 | (R)-7; AZD2716 | IC50 | = | 176 | nM | ALA4431203 | 6.75 | nM | Homo sapiens | ||
| 2. | ALA4593409 | (R)-7; AZD2716 | INH | 0 | ALA4431202 | Dose-dependent effect | % | Macaca fascicularis | ||||
| 3. | ALA4593409 | (R)-7; AZD2716 | fIC80 | = | 13 | nM | ALA4431202 | nM | Macaca fascicularis | |||
| 4. | ALA4593409 | (R)-7; AZD2716 | fIC50 | = | 1 | nM | ALA4431201 | nM | ||||
| 5. | ALA4593409 | (R)-7; AZD2716 | IC50 | = | 56 | nM | ALA4431200 | 7.25 | nM | Homo sapiens | ||
| 6. | ALA4593409 | (R)-7; AZD2716 | IC50 | < | 14 | nM | ALA4431199 | nM | Homo sapiens | |||
| 7. | ALA4593409 | (R)-7; AZD2716 | F | = | 81 | % | ALA4431198 | % | ||||
| 8. | ALA4593409 | (R)-7; AZD2716 | Vdss | = | 1.1 | L/Kg | ALA4431197 | L.kg-1 | ||||
| 9. | ALA4593409 | (R)-7; AZD2716 | CL | = | 2.8 | ml/min.kg | ALA4431196 | mL.min-1.kg-1 | ||||
| 10. | ALA4593409 | (R)-7; AZD2716 | AUC | = | 71.3 | uM.hr | ALA4431195 | standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | ng.hr.mL-1 | |||
| 11. | ALA4593409 | (R)-7; AZD2716 | F | = | 91 | % | ALA4431194 | % | ||||
| 12. | ALA4593409 | (R)-7; AZD2716 | Vdss | = | 0.15 | L/Kg | ALA4431193 | L.kg-1 | ||||
| 13. | ALA4593409 | (R)-7; AZD2716 | CL | = | 0.2 | ml/min.kg | ALA4431192 | mL.min-1.kg-1 | ||||
| 14. | ALA4593409 | (R)-7; AZD2716 | AUC | = | 284.1 | uM.hr | ALA4431191 | standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | ng.hr.mL-1 | |||
| 15. | ALA4593409 | (R)-7; AZD2716 | F | = | 84 | % | ALA4431190 | % | ||||
| 16. | ALA4593409 | (R)-7; AZD2716 | Vdss | = | 0.21 | L/Kg | ALA4431189 | L.kg-1 | ||||
| 17. | ALA4593409 | (R)-7; AZD2716 | CL | = | 1 | ml/min.kg | ALA4431188 | mL.min-1.kg-1 | ||||
| 18. | ALA4593409 | (R)-7; AZD2716 | AUC | = | 70 | uM.hr | ALA4431187 | standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | ng.hr.mL-1 | |||
| 19. | ALA4593409 | (R)-7; AZD2716 | F | = | 76.3 | % | ALA4431186 | % | ||||
| 20. | ALA4593409 | (R)-7; AZD2716 | Vdss | = | 2.8 | L/Kg | ALA4431185 | L.kg-1 |
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