# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA4635911 | 15m | TGI | 0 | ALA4619438 | Dose-dependent effect | Homo sapiens | |||||
2. | ALA4635911 | 15m | Activity | 0 | ALA4619437 | Non-Toxic | ||||||
3. | ALA4635911 | 15m | Activity | 0 | ALA4619436 | Non-Toxic | ||||||
4. | ALA4635911 | 15m | Activity | 0 | ALA4619435 | Toxic | ||||||
5. | ALA4635911 | 15m | Ratio IC50 | = | 9 | ALA4619434 | ||||||
6. | ALA4635911 | 15m | Ratio IC50 | = | 9 | ALA4619433 | ||||||
7. | ALA4635911 | 15m | Ratio IC50 | = | 9 | ALA4619432 | ||||||
8. | ALA4635911 | 15m | Ratio IC50 | = | 9 | ALA4619431 | ||||||
9. | ALA4635911 | 15m | Ratio IC50 | = | 9 | ALA4619430 | ||||||
10. | ALA4635911 | 15m | Activity | 0 | ALA4619429 | Non-Toxic | ||||||
11. | ALA4635911 | 15m | Activity | = | 5 | % | ALA4619393 | % | ||||
12. | ALA4635911 | 15m | TGI | = | 72.5 | % | ALA4619428 | % | Homo sapiens | |||
13. | ALA4635911 | 15m | TGI | = | 64 | % | ALA4619427 | % | Homo sapiens | |||
14. | ALA4635911 | 15m | LD50 | = | 287 | mg kg-1 | ALA4619426 | mg.kg-1 | ||||
15. | ALA4635911 | 15m | F | = | 23.5 | % | ALA4619425 | % | ||||
16. | ALA4635911 | 15m | AUC | = | 940 | ng.hr/ml | ALA4619424 | ng.hr.mL-1 | ||||
17. | ALA4635911 | 15m | Cmax | = | 617 | ng/ml | ALA4619423 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | |||
18. | ALA4635911 | 15m | Vdss(app) | = | 5.26 | L/Kg | ALA4619422 | L.kg-1 | ||||
19. | ALA4635911 | 15m | CL | = | 26.68 | L/kg/hr | ALA4619421 | mL.min-1.kg-1 | ||||
20. | ALA4635911 | 15m | beta t1/2 | = | 3.7 | hr | ALA4619420 | hr |