| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA4644994 | (+/-)-35 | F | = | 47 | % | ALA4614766 | % | ||||
| 2. | ALA4644994 | (+/-)-35 | Cmax | = | 5410 | nM | ALA4614765 | nM | ||||
| 3. | ALA4644994 | (+/-)-35 | AUClast | = | 17100 | nM.hr | ALA4614764 | standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | ng.hr.mL-1 | |||
| 4. | ALA4644994 | (+/-)-35 | MRT | = | 2.3 | hr | ALA4614763 | hr | ||||
| 5. | ALA4644994 | (+/-)-35 | t1/2 | = | 4.9 | hr | ALA4614762 | hr | ||||
| 6. | ALA4644994 | (+/-)-35 | Vdss | = | 3.1 | L/Kg | ALA4614761 | L.kg-1 | ||||
| 7. | ALA4644994 | (+/-)-35 | CL | = | 6.8 | ml/min.kg | ALA4614760 | mL.min-1.kg-1 | ||||
| 8. | ALA4644994 | (+/-)-35 | Papp | = | 0.6 | 10'-6 cm/s | ALA4614759 | 10'-6 cm/s | ||||
| 9. | ALA4644994 | (+/-)-35 | Papp | = | 16.6 | 10'-6 cm/s | ALA4614758 | 10'-6 cm/s | ||||
| 10. | ALA4644994 | (+/-)-35 | CLH | = | 54.1 | microL/min/mg | ALA4614757 | mL.min-1.g-1 | ||||
| 11. | ALA4644994 | (+/-)-35 | CLH | < | 3.4 | microL/min/mg | ALA4614756 | mL.min-1.g-1 | ||||
| 12. | ALA4644994 | (+/-)-35 | solubility | = | 0.98 | mM | ALA4614755 | nM | ||||
| 13. | ALA4644994 | (+/-)-35 | IC50 | = | 2.28 | uM | ALA4614754 | 5.64 | nM | Mus musculus | ||
| 14. | ALA4644994 | (+/-)-35 | IC50 | = | 0.25 | uM | ALA4614753 | 6.60 | nM | Homo sapiens | ||
| 15. | ALA4644994 | (+/-)-35 | IC50 | = | 0.033 | uM | ALA4614752 | 7.48 | nM | Homo sapiens | ||
| 16. | ALA4644994 | (+/-)-35 | IC50 | = | 17 | uM | ALA4614752 | 4.77 | nM | Homo sapiens | ||
| 17. | ALA4644994 | (+/-)-35 | IC50 | = | 0.062 | uM | ALA4614752 | 7.21 | nM | Homo sapiens | ||
| 18. | ALA4644994 | (+/-)-35 | IC50 | > | 30 | uM | ALA4614750 | nM | Homo sapiens | |||
| 19. | ALA4644994 | (+/-)-35 | IC50 | > | 30 | uM | ALA4614749 | nM | Homo sapiens | |||
| 20. | ALA4644994 | (+/-)-35 | IC50 | > | 30 | uM | ALA4614748 | nM | Homo sapiens |
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