# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA4646281 | 43 | MRTlast | = | 0.59 | hr | ALA4603838 | hr | ||||
2. | ALA4646281 | 43 | Vdss | = | 1.27 | L/Kg | ALA4603837 | L.kg-1 | ||||
3. | ALA4646281 | 43 | CL | = | 34.4 | ml/min/mg | ALA4603836 | mL.min-1.g-1 | ||||
4. | ALA4646281 | 43 | Vz | = | 1.85 | L/Kg | ALA4603835 | L.kg-1 | ||||
5. | ALA4646281 | 43 | AUC | = | 976 | ng.hr/ml | ALA4603834 | ng.hr.mL-1 | ||||
6. | ALA4646281 | 43 | AUCt | = | 974 | ng.hr/ml | ALA4603833 | ng.hr.mL-1 | ||||
7. | ALA4646281 | 43 | t1/2 | = | 0.62 | hr | ALA4603832 | hr | ||||
8. | ALA4646281 | 43 | GI50 | = | 19 | uM | ALA4603831 | nM | Homo sapiens | |||
9. | ALA4646281 | 43 | GI50 | = | 5.4 | uM | ALA4603830 | nM | Homo sapiens | |||
10. | ALA4646281 | 43 | GI50 | = | 3.4 | uM | ALA4603829 | nM | Homo sapiens | |||
11. | ALA4646281 | 43 | GI50 | = | 3.7 | uM | ALA4603828 | nM | Homo sapiens | |||
12. | ALA4646281 | 43 | GI50 | = | 5.1 | uM | ALA4603827 | nM | Homo sapiens | |||
13. | ALA4646281 | 43 | INH | 0 | ALA4603826 | Not Active | % | Homo sapiens | ||||
14. | ALA4646281 | 43 | INH | 0 | ALA4603825 | Active | % | Homo sapiens | ||||
15. | ALA4646281 | 43 | INH | = | 100 | % | ALA4603824 | % | Homo sapiens | |||
16. | ALA4646281 | 43 | INH | 0 | ALA4603823 | Active | % | Homo sapiens | ||||
17. | ALA4646281 | 43 | EC50 | = | 119 | nM | ALA4603822 | 6.92 | nM | Homo sapiens | ||
18. | ALA4646281 | 43 | INH | = | 100 | % | ALA4603821 | % | Homo sapiens | |||
19. | ALA4646281 | 43 | Ratio IC50 | = | 39 | ALA4603820 | ||||||
20. | ALA4646281 | 43 | Ratio IC50 | = | 590 | ALA4603819 |