# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA4740657 | 14 | AUClast | = | 217513 | hr.ng/ml | ALA4689797 | ng.hr.mL-1 | ||||
2. | ALA4740657 | 14 | Activity | 0 | ALA4689792 | Toxic | ||||||
3. | ALA4740657 | 14 | Activity | 0 | ALA4689791 | Toxic | ||||||
4. | ALA4740657 | 14 | PPB | = | 99.79 | % | ALA4689790 | % | ||||
5. | ALA4740657 | 14 | PPB | = | 99.68 | % | ALA4689789 | % | ||||
6. | ALA4740657 | 14 | Cmax | = | 44100 | ng/ml | ALA4689787 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | |||
7. | ALA4740657 | 14 | Papp | = | 10.8 | 10^-6 cm/s | ALA4689783 | 10^-6 cm/s | ||||
8. | ALA4740657 | 14 | Kinetic_solubility | = | 25.1 | uM | ALA4689782 | nM | ||||
9. | ALA4740657 | 14 | Kinetic_solubility | = | 21.1 | uM | ALA4689781 | nM | ||||
10. | ALA4740657 | 14 | t1/2 | = | 30.2 | min | ALA4689780 | hr | ||||
11. | ALA4740657 | 14 | t1/2 | = | 124 | min | ALA4689779 | hr | ||||
12. | ALA4740657 | 14 | IC50 | = | 27 | nM | ALA4689778 | 7.57 | nM | Homo sapiens | ||
13. | ALA4740657 | 14 | Ki | = | 8 | nM | ALA4689777 | 8.10 | nM | Homo sapiens |