# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA4741793 | 31 | IC50 | = | 40 | nM | ALA5217093 | 7.40 | nM | Homo sapiens | ||
2. | ALA4741793 | 31 | Activity | 0 | ALA4714806 | Non-Toxic | ||||||
3. | ALA4741793 | 31 | Drug uptake | = | 1204 | nM | ALA4714805 | nM | ||||
4. | ALA4741793 | 31 | Drug uptake(free) | = | 270 | nM | ALA4714804 | nM | ||||
5. | ALA4741793 | 31 | Activity | 0 | ALA4714803 | Non-Toxic | ||||||
6. | ALA4741793 | 31 | Activity | 0 | ALA4714802 | Active | Mus musculus | |||||
7. | ALA4741793 | 31 | Activity | 0 | ALA4714801 | Active | Mus musculus | |||||
8. | ALA4741793 | 31 | PB | = | 97.8 | % | ALA4714800 | % | ||||
9. | ALA4741793 | 31 | PPB | = | 98.3 | % | ALA4714799 | % | ||||
10. | ALA4741793 | 31 | F | = | 100 | % | ALA4714798 | % | ||||
11. | ALA4741793 | 31 | t1/2 | = | 20 | hr | ALA4714797 | hr | ||||
12. | ALA4741793 | 31 | Vdss | = | 1.88 | L/Kg | ALA4714796 | L.kg-1 | ||||
13. | ALA4741793 | 31 | CL | = | 2 | ml/min.kg | ALA4714795 | mL.min-1.kg-1 | ||||
14. | ALA4741793 | 31 | IC50 | = | 16.4 | uM | ALA4714794 | 4.79 | nM | Homo sapiens | ||
15. | ALA4741793 | 31 | IC50 | = | 13.2 | uM | ALA4714793 | 4.88 | nM | Homo sapiens | ||
16. | ALA4741793 | 31 | IC50 | = | 18.5 | uM | ALA4714792 | 4.73 | nM | Homo sapiens | ||
17. | ALA4741793 | 31 | IC50 | = | 10.7 | uM | ALA4714791 | 4.97 | nM | Homo sapiens | ||
18. | ALA4741793 | 31 | IC50 | = | 42 | uM | ALA4714790 | 4.38 | nM | Homo sapiens | ||
19. | ALA4741793 | 31 | IC50 | = | 11.9 | uM | ALA4714789 | 4.92 | nM | Homo sapiens | ||
20. | ALA4741793 | 31 | Activity | = | 74 | % | ALA4714788 | % |