| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA4753981 | 12 | pKa | = | 7.4 | ALA4703127 | ||||||
| 2. | ALA4753981 | 12 | Cp | = | 26 | uM | ALA4703126 | uM | ||||
| 3. | ALA4753981 | 12 | Cp | = | 7 | uM | ALA4703125 | uM | ||||
| 4. | ALA4753981 | 12 | INH | 0 | ALA4703124 | Dose-dependent effect | % | |||||
| 5. | ALA4753981 | 12 | INH | = | 55 | % | ALA4703123 | % | ||||
| 6. | ALA4753981 | 12 | IC50 | = | 9.5 | uM | ALA4703122 | 5.02 | nM | Mus musculus | ||
| 7. | ALA4753981 | 12 | IC50 | = | 2.2 | uM | ALA4703121 | 5.66 | nM | Homo sapiens | ||
| 8. | ALA4753981 | 12 | IC50 | = | 32 | nM | ALA4703120 | 7.50 | nM | Homo sapiens | ||
| 9. | ALA4753981 | 12 | IC50 | = | 80 | nM | ALA4703118 | 7.10 | nM | Homo sapiens | ||
| 10. | ALA4753981 | 12 | Fu | = | 36 | % | ALA4703117 | |||||
| 11. | ALA4753981 | 12 | Fu | = | 17 | % | ALA4703116 | |||||
| 12. | ALA4753981 | 12 | t1/2 | = | 2 | hr | ALA4703115 | hr | ||||
| 13. | ALA4753981 | 12 | AUC | = | 47.9 | uM.hr | ALA4703114 | standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | ng.hr.mL-1 | |||
| 14. | ALA4753981 | 12 | Cmax | = | 13 | uM | ALA4703113 | nM | ||||
| 15. | ALA4753981 | 12 | IC50 | = | 6.6 | uM | ALA4703112 | 5.18 | nM | Homo sapiens | ||
| 16. | ALA4753981 | 12 | IC50 | > | 10 | uM | ALA4703111 | nM | Homo sapiens | |||
| 17. | ALA4753981 | 12 | IC50 | > | 10 | uM | ALA4703110 | nM | Homo sapiens | |||
| 18. | ALA4753981 | 12 | IC50 | > | 10 | uM | ALA4703109 | nM | Homo sapiens | |||
| 19. | ALA4753981 | 12 | IC50 | > | 10 | uM | ALA4703108 | nM | Homo sapiens | |||
| 20. | ALA4753981 | 12 | permeability | = | 313 | nm/s | ALA4703107 | nm/s |
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