# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA4761283 | 6i | INH | 0 | ALA4727631 | Dose-dependent effect | % | |||||
2. | ALA4761283 | 6i | Activity | = | 0.276 | g | ALA4727630 | g | ||||
3. | ALA4761283 | 6i | Activity | = | 0.099 | g | ALA4727629 | g | ||||
4. | ALA4761283 | 6i | Activity | = | 62.8 | % | ALA4727626 | % | Rattus norvegicus | |||
5. | ALA4761283 | 6i | Activity | = | 38.4 | % | ALA4727625 | % | Rattus norvegicus | |||
6. | ALA4761283 | 6i | F | = | 17.4 | % | ALA4727617 | % | ||||
7. | ALA4761283 | 6i | Tmax | = | 0.42 | hr | ALA4727616 | hr | ||||
8. | ALA4761283 | 6i | Cmax | = | 549 | ng/ml | ALA4727615 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | |||
9. | ALA4761283 | 6i | AUC | = | 2701 | hr.ng/ml | ALA4727614 | ng.hr.mL-1 | ||||
10. | ALA4761283 | 6i | t1/2 | = | 4.85 | hr | ALA4727613 | hr | ||||
11. | ALA4761283 | 6i | Vdss | = | 1.89 | L/Kg | ALA4727612 | L.kg-1 | ||||
12. | ALA4761283 | 6i | CL | = | 10.9 | ml/min.kg | ALA4727611 | mL.min-1.kg-1 | ||||
13. | ALA4761283 | 6i | Stabilty | = | 58 | % | ALA4727610 | % | ||||
14. | ALA4761283 | 6i | Stabilty | = | 97 | % | ALA4727609 | % | ||||
15. | ALA4761283 | 6i | Stabilty | = | 90 | % | ALA4727607 | % | ||||
16. | ALA4761283 | 6i | IC50 | = | 1.1 | nM | ALA4727604 | 8.96 | nM | Homo sapiens | ||
17. | ALA4761283 | 6i | IC50 | = | 34 | nM | ALA4727603 | 7.47 | nM | Homo sapiens |