| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA4761666 | 7; DSM424 | Ratio | = | 0.7 | ALA4706918 | ||||||
| 2. | ALA4761666 | 7; DSM424 | PPB | = | 99.2 | % | ALA4706912 | % | ||||
| 3. | ALA4761666 | 7; DSM424 | PPB | = | 99.2 | % | ALA4706907 | % | ||||
| 4. | ALA4761666 | 7; DSM424 | fAUC | = | 0.19 | uM.hr | ALA4706897 | uM.hr | ||||
| 5. | ALA4761666 | 7; DSM424 | AUCED90 | > | 23 | uM.hr/day | ALA4706872 | uM.hr/day | Plasmodium falciparum | |||
| 6. | ALA4761666 | 7; DSM424 | ED90 | > | 30 | mg kg-1 | ALA4706870 | mg kg-1 | Plasmodium falciparum | |||
| 7. | ALA4761666 | 7; DSM424 | F | = | 100 | % | ALA4706868 | % | ||||
| 8. | ALA4761666 | 7; DSM424 | fAUC | = | 1.82 | uM.hr | ALA4706863 | uM.hr | ||||
| 9. | ALA4761666 | 7; DSM424 | AUC | = | 227 | uM.hr | ALA4706858 | standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | ng.hr.mL-1 | |||
| 10. | ALA4761666 | 7; DSM424 | fCmax | = | 0.19 | uM | ALA4706853 | uM | ||||
| 11. | ALA4761666 | 7; DSM424 | Cmax | = | 23.8 | uM | ALA4706848 | nM | ||||
| 12. | ALA4761666 | 7; DSM424 | Tmax | = | 4 | hr | ALA4706845 | hr | ||||
| 13. | ALA4761666 | 7; DSM424 | fVdss | = | 188 | L/Kg | ALA4706840 | L/Kg | ||||
| 14. | ALA4761666 | 7; DSM424 | Vdss | = | 1.5 | L/Kg | ALA4706835 | L.kg-1 | ||||
| 15. | ALA4761666 | 7; DSM424 | CL free | = | 438 | ml/min.kg | ALA4706830 | mL.min-1.kg-1 | ||||
| 16. | ALA4761666 | 7; DSM424 | CL | = | 3.5 | ml/min.kg | ALA4706825 | mL.min-1.kg-1 | ||||
| 17. | ALA4761666 | 7; DSM424 | AUC | = | 24 | uM.hr | ALA4706820 | standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | ng.hr.mL-1 | |||
| 18. | ALA4761666 | 7; DSM424 | t1/2(app) | = | 7.1 | hr | ALA4706815 | hr | ||||
| 19. | ALA4761666 | 7; DSM424 | beta t1/2 | = | 2 | hr | ALA4706811 | hr | ||||
| 20. | ALA4761666 | 7; DSM424 | fAUC | = | 0.16 | uM.hr | ALA4706810 | uM.hr |
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