| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA4762256 | 12a | Ratio IC50 | = | 76 | ALA4716887 | ||||||
| 2. | ALA4762256 | 12a | IC50 | = | 3 | nM | ALA4716886 | 8.52 | nM | Homo sapiens | ||
| 3. | ALA4762256 | 12a | F | = | 35 | % | ALA4716881 | % | ||||
| 4. | ALA4762256 | 12a | AUC | = | 7187 | hr.nM | ALA4716880 | standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | ng.hr.mL-1 | |||
| 5. | ALA4762256 | 12a | Cmax | = | 291 | nM | ALA4716879 | nM | ||||
| 6. | ALA4762256 | 12a | Vdss | = | 13.7 | L/Kg | ALA4716878 | L.kg-1 | ||||
| 7. | ALA4762256 | 12a | CL | = | 15 | ml/min.kg | ALA4716877 | mL.min-1.kg-1 | ||||
| 8. | ALA4762256 | 12a | F | = | 59 | % | ALA4716876 | % | ||||
| 9. | ALA4762256 | 12a | AUC | = | 5980 | hr.nM | ALA4716875 | standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | ng.hr.mL-1 | |||
| 10. | ALA4762256 | 12a | Cmax | = | 425 | nM | ALA4716874 | nM | ||||
| 11. | ALA4762256 | 12a | Vdss | = | 10.8 | L/Kg | ALA4716873 | L.kg-1 | ||||
| 12. | ALA4762256 | 12a | CL | = | 58 | ml/min.kg | ALA4716872 | mL.min-1.kg-1 | ||||
| 13. | ALA4762256 | 12a | IC50 | = | 1.7 | uM | ALA4716871 | 5.77 | nM | Homo sapiens | ||
| 14. | ALA4762256 | 12a | permeability | = | 1.1 | cm/s | ALA4716869 | cm/s | ||||
| 15. | ALA4762256 | 12a | permeability | = | 1.3 | cm/s | ALA4716868 | cm/s | ||||
| 16. | ALA4762256 | 12a | log(permeability) | < | -3.3 | ALA4716867 | ||||||
| 17. | ALA4762256 | 12a | solubility | = | 10.4 | uM | ALA4716866 | nM | ||||
| 18. | ALA4762256 | 12a | IC50 | = | 4.5 | uM | ALA4716865 | 5.35 | nM | Homo sapiens | ||
| 19. | ALA4762256 | 12a | CLH | = | 25 | microL/min/mg | ALA4716864 | mL.min-1.g-1 | ||||
| 20. | ALA4762256 | 12a | CLH | = | 34 | microL/min/mg | ALA4716863 | mL.min-1.g-1 |
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