# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA4778367 | 10b | IC50 | = | 94.7 | nM | ALA4768630 | 7.02 | nM | Homo sapiens | ||
2. | ALA4778367 | 10b | IC50 | = | 18.9 | nM | ALA4768629 | 7.72 | nM | Homo sapiens | ||
3. | ALA4778367 | 10b | IC50 | = | 309.2 | nM | ALA4768628 | 6.51 | nM | Homo sapiens | ||
4. | ALA4778367 | 10b | Activity | < | 20 | % | ALA4768627 | % | ||||
5. | ALA4778367 | 10b | Activity | < | 20 | % | ALA4768626 | % | ||||
6. | ALA4778367 | 10b | Activity | < | 20 | % | ALA4768625 | % | ||||
7. | ALA4778367 | 10b | T/C | = | 53 | % | ALA4768624 | % | Homo sapiens | |||
8. | ALA4778367 | 10b | TGI | = | 54 | % | ALA4768623 | % | Homo sapiens | |||
9. | ALA4778367 | 10b | T/C | = | 52 | % | ALA4768622 | % | Homo sapiens | |||
10. | ALA4778367 | 10b | T/C | = | 33 | % | ALA4768621 | % | Homo sapiens | |||
11. | ALA4778367 | 10b | Activity | 0 | ALA4768620 | Active | Homo sapiens | |||||
12. | ALA4778367 | 10b | Activity | 0 | ALA4768619 | Active | Homo sapiens | |||||
13. | ALA4778367 | 10b | TGI | = | 85 | % | ALA4768618 | % | Homo sapiens | |||
14. | ALA4778367 | 10b | TGI | = | 63 | % | ALA4768617 | % | Homo sapiens | |||
15. | ALA4778367 | 10b | TGI | 0 | ALA4768616 | Dose-dependent effect | Homo sapiens | |||||
16. | ALA4778367 | 10b | F | = | 65.2 | % | ALA4768615 | % | ||||
17. | ALA4778367 | 10b | t1/2 | = | 4.96 | hr | ALA4768614 | hr | ||||
18. | ALA4778367 | 10b | AUCt | = | 1118 | ng.hr/ml | ALA4768613 | ng.hr.mL-1 | ||||
19. | ALA4778367 | 10b | Cmax | = | 110 | ng/ml | ALA4768612 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | |||
20. | ALA4778367 | 10b | CL | = | 130 | ml/min.kg | ALA4768611 | mL.min-1.kg-1 |