# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA4781713 | 27 | ED90 | = | 2.6 | mg kg-1 | ALA4681008 | mg kg-1 | Plasmodium berghei | |||
2. | ALA4781713 | 27 | Survival | = | 6 | day | ALA4680999 | day | Plasmodium berghei | |||
3. | ALA4781713 | 27 | Activity | = | 48 | % | ALA4680998 | % | Plasmodium berghei | |||
4. | ALA4781713 | 27 | Survival | = | 9 | day | ALA4680997 | day | Plasmodium berghei | |||
5. | ALA4781713 | 27 | Activity | = | 96 | % | ALA4680996 | % | Plasmodium berghei | |||
6. | ALA4781713 | 27 | Survival | = | 15 | day | ALA4680994 | day | Plasmodium berghei | |||
7. | ALA4781713 | 27 | Activity | = | 99.7 | % | ALA4680993 | % | Plasmodium berghei | |||
8. | ALA4781713 | 27 | Survival | = | 22 | day | ALA4680991 | day | Plasmodium berghei | |||
9. | ALA4781713 | 27 | Activity | = | 99.8 | % | ALA4680990 | % | Plasmodium berghei | |||
10. | ALA4781713 | 27 | F | = | 16 | % | ALA4680989 | % | ||||
11. | ALA4781713 | 27 | Tmax | = | 2 | hr | ALA4680988 | hr | ||||
12. | ALA4781713 | 27 | AUC | = | 176115 | ng.min/ml | ALA4680987 | ng.hr.mL-1 | ||||
13. | ALA4781713 | 27 | Cmax | = | 579 | ng/ml | ALA4680986 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | |||
14. | ALA4781713 | 27 | t1/2 | = | 12.5 | hr | ALA4680985 | hr | ||||
15. | ALA4781713 | 27 | Vdss | = | 3.5 | L/Kg | ALA4680984 | L.kg-1 | ||||
16. | ALA4781713 | 27 | CL | = | 4 | ml/min.kg | ALA4680983 | mL.min-1.kg-1 | ||||
17. | ALA4781713 | 27 | IC50 | > | 11 | uM | ALA4680981 | nM | Homo sapiens | |||
18. | ALA4781713 | 27 | PPB | = | 49 | % | ALA4680980 | % | ||||
19. | ALA4781713 | 27 | CLH | < | 1 | ml/min/g | ALA4680979 | mL.min-1.g-1 | ||||
20. | ALA4781713 | 27 | permeability | = | 2 | nm/s | ALA4680977 | nm/s |