# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA4791261 | 13 | AUClast | = | 158570 | hr.ng/ml | ALA4689797 | ng.hr.mL-1 | ||||
2. | ALA4791261 | 13 | Ki | = | 1 | nM | ALA4689796 | 9.00 | nM | Rattus norvegicus | ||
3. | ALA4791261 | 13 | Activity | 0 | ALA4689795 | Active | ||||||
4. | ALA4791261 | 13 | Activity | 0 | ALA4689794 | Active | ||||||
5. | ALA4791261 | 13 | Activity | 0 | ALA4689793 | Active | Rattus norvegicus | |||||
6. | ALA4791261 | 13 | Activity | 0 | ALA4689792 | Toxic | ||||||
7. | ALA4791261 | 13 | Activity | 0 | ALA4689791 | Toxic | ||||||
8. | ALA4791261 | 13 | PPB | = | 99.99 | % | ALA4689790 | % | ||||
9. | ALA4791261 | 13 | PPB | = | 99.92 | % | ALA4689789 | % | ||||
10. | ALA4791261 | 13 | F | = | 97.7 | % | ALA4689788 | % | ||||
11. | ALA4791261 | 13 | Cmax | = | 24625 | ng/ml | ALA4689787 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | |||
12. | ALA4791261 | 13 | t1/2 | = | 4.6 | hr | ALA4689786 | hr | ||||
13. | ALA4791261 | 13 | Vdss | = | 0.23 | L/Kg | ALA4689785 | L.kg-1 | ||||
14. | ALA4791261 | 13 | CL | = | 1.06 | ml/min.kg | ALA4689784 | mL.min-1.kg-1 | ||||
15. | ALA4791261 | 13 | Papp | = | 9.9 | 10^-6 cm/s | ALA4689783 | 10^-6 cm/s | ||||
16. | ALA4791261 | 13 | Kinetic_solubility | = | 8 | uM | ALA4689782 | nM | ||||
17. | ALA4791261 | 13 | Kinetic_solubility | = | 28 | uM | ALA4689781 | nM | ||||
18. | ALA4791261 | 13 | t1/2 | > | 180 | min | ALA4689780 | hr | ||||
19. | ALA4791261 | 13 | t1/2 | > | 180 | min | ALA4689779 | hr | ||||
20. | ALA4791261 | 13 | IC50 | = | 21 | nM | ALA4689778 | 7.68 | nM | Homo sapiens |