# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA4798343 | 7a | INH | 0 | ALA4678752 | Not Active | % | |||||
2. | ALA4798343 | 7a | INH | 0 | ALA4678751 | Not Active | % | |||||
3. | ALA4798343 | 7a | INH | 0 | ALA4678750 | Active | % | |||||
4. | ALA4798343 | 7a | INH | 0 | ALA4678749 | Active | % | |||||
5. | ALA4798343 | 7a | Activity | = | 14.8 | % | ALA4678748 | % | ||||
6. | ALA4798343 | 7a | INH | 0 | ALA4678747 | Active | % | Homo sapiens | ||||
7. | ALA4798343 | 7a | TGI | = | 88.7 | % | ALA4678746 | % | Homo sapiens | |||
8. | ALA4798343 | 7a | TGI | = | 75.5 | % | ALA4678745 | % | Homo sapiens | |||
9. | ALA4798343 | 7a | TGI | 0 | ALA4678744 | Dose-dependent effect | Homo sapiens | |||||
10. | ALA4798343 | 7a | F | = | 54.5 | % | ALA4678743 | % | ||||
11. | ALA4798343 | 7a | AUC | = | 142 | hr.microg/ml | ALA4678742 | ng.hr.mL-1 | ||||
12. | ALA4798343 | 7a | AUCt | = | 126.3 | hr.microg/ml | ALA4678741 | ng.hr.mL-1 | ||||
13. | ALA4798343 | 7a | Cmax | = | 9.61 | ug ml-1 | ALA4678740 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | |||
14. | ALA4798343 | 7a | t1/2 | = | 6.3 | hr | ALA4678739 | hr | ||||
15. | ALA4798343 | 7a | AUC | = | 25.3 | hr.microg/ml | ALA4678738 | ng.hr.mL-1 | ||||
16. | ALA4798343 | 7a | AUCt | = | 23.16 | hr.microg/ml | ALA4678737 | ng.hr.mL-1 | ||||
17. | ALA4798343 | 7a | Vdss | = | 513 | ml/kg | ALA4678736 | L.kg-1 | ||||
18. | ALA4798343 | 7a | CL | = | 159 | ml/hr/kg | ALA4678735 | mL.min-1.kg-1 | ||||
19. | ALA4798343 | 7a | t1/2 | = | 2.25 | hr | ALA4678734 | hr | ||||
20. | ALA4798343 | 7a | Fu | = | 0.3 | % | ALA4678733 |