# | Name | Compound Key | Action Type | Relation | Activety Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA4859677 | 8a | AUC | = | 429 | hr.ng/ml | ALA4834881 | ng.hr.mL-1 | ||||
2. | ALA4859677 | 8a | AUC | = | 527 | hr.ng/ml | ALA4834879 | ng.hr.mL-1 | ||||
3. | ALA4859677 | 8a | Cmax | = | 836 | uM | ALA4834878 | nM | ||||
4. | ALA4859677 | 8a | Cmax | = | 519 | uM | ALA4834876 | nM | ||||
5. | ALA4859677 | 8a | t1/2 | = | 0.54 | hr | ALA4834875 | hr | ||||
6. | ALA4859677 | 8a | t1/2 | = | 0.5 | hr | ALA4834873 | hr | ||||
7. | ALA4859677 | 8a | F | = | 18.2 | % | ALA4834872 | % | ||||
8. | ALA4859677 | 8a | F | = | 15.7 | % | ALA4834870 | % | ||||
9. | ALA4859677 | 8a | Activity | = | 1661 | ng/ml | ALA4834869 | ng/ml | ||||
10. | ALA4859677 | 8a | Activity | = | 1647 | ng/ml | ALA4834866 | ng/ml | ||||
11. | ALA4859677 | 8a | t1/2 | = | 0.12 | hr | ALA4834865 | hr | ||||
12. | ALA4859677 | 8a | t1/2 | = | 0.21 | hr | ALA4834862 | hr | ||||
13. | ALA4859677 | 8a | Vdss | = | 51 | L/Kg | ALA4834861 | L.kg-1 | ||||
14. | ALA4859677 | 8a | Vdss | = | 0.69 | L/Kg | ALA4834858 | L.kg-1 | ||||
15. | ALA4859677 | 8a | CL | = | 70.7 | ml/min.kg | ALA4834856 | mL.min-1.kg-1 | ||||
16. | ALA4859677 | 8a | CL | = | 57.8 | ml/min.kg | ALA4834854 | mL.min-1.kg-1 | ||||
17. | ALA4859677 | 8a | EC50 | = | 0.33 | nM | ALA4834853 | 9.48 | nM | Homo sapiens | ||
18. | ALA4859677 | 8a | CLH | = | 63.1 | uL/min | ALA4834852 | uL/min | ||||
19. | ALA4859677 | 8a | CLH | = | 46 | uL/min | ALA4834851 | uL/min | ||||
20. | ALA4859677 | 8a | CLH | = | 12.3 | uL/min | ALA4834850 | uL/min |