| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  IACS-8968 R-enantiomer | (R)-17 | INH | = | 86 | % | ALA4843302 | % | Mus musculus | |||
| 2. | IACS-8968 R-enantiomer | (R)-17 | PPB | = | 93.8 | % | ALA4843301 | % | ||||
| 3. | IACS-8968 R-enantiomer | (R)-17 | Cp | = | 0.1 | uM | ALA4843296 | uM | ||||
| 4. | IACS-8968 R-enantiomer | (R)-17 | Drug uptake | = | 0.7 | uM | ALA4843292 | uM | ||||
| 5. | IACS-8968 R-enantiomer | (R)-17 | IC50 | = | 23 | uM | ALA4843280 | 4.64 | nM | Homo sapiens | ||
| 6. | IACS-8968 R-enantiomer | (R)-17 | Activity | = | 10 | % | ALA4843259 | % | Mus musculus | |||
| 7. | IACS-8968 R-enantiomer | (R)-17 | IC50 | > | 30 | uM | ALA4843252 | nM | Homo sapiens | |||
| 8. | IACS-8968 R-enantiomer | (R)-17 | Ratio IC50 | > | 1200 | ALA4843251 | ||||||
| 9. | IACS-8968 R-enantiomer | (R)-17 | F | = | 132 | % | ALA4843249 | % | ||||
| 10. | IACS-8968 R-enantiomer | (R)-17 | Cmax | = | 7 | uM | ALA4843248 | nM | ||||
| 11. | IACS-8968 R-enantiomer | (R)-17 | AUC | = | 0.45 | uM.hr | ALA4843247 | standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | ng.hr.mL-1 | |||
| 12. | IACS-8968 R-enantiomer | (R)-17 | beta t1/2 | = | 0.848 | hr | ALA4843246 | hr | ||||
| 13. | IACS-8968 R-enantiomer | (R)-17 | Vdss | = | 2.1 | L/Kg | ALA4843245 | L.kg-1 | ||||
| 14. | IACS-8968 R-enantiomer | (R)-17 | CL | = | 1.4 | L/hr/kg | ALA4843244 | mL.min-1.kg-1 | ||||
| 15. | IACS-8968 R-enantiomer | (R)-17 | CLH | = | 21 | ml/min.kg | ALA4843239 | mL.min-1.kg-1 | ||||
| 16. | IACS-8968 R-enantiomer | (R)-17 | CLH | = | 37 | ml/min.kg | ALA4843238 | mL.min-1.kg-1 | ||||
| 17. | IACS-8968 R-enantiomer | (R)-17 | IC50 | = | 61 | nM | ALA4843237 | 7.21 | nM | Homo sapiens | ||
| 18. | IACS-8968 R-enantiomer | (R)-17 | IC50 | = | 68 | nM | ALA4843236 | 7.17 | nM | Homo sapiens | ||
| 19. | IACS-8968 R-enantiomer | (R)-17 | IC50 | = | 23 | nM | ALA4843234 | 7.64 | nM | Mus musculus |
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