| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  I-BET282 | 32; I-BET282 | pIC50 | = | 7.4 | ALA5218149 | 7.40 | nM | Homo sapiens | |||
| 2. | I-BET282 | 32; I-BET282 | pIC50 | = | 6.9 | ALA5218148 | 6.90 | nM | Homo sapiens | |||
| 3. | I-BET282 | 32; I-BET282 | permeability | = | 346 | nm/s | ALA4843842 | nm/s | ||||
| 4. | I-BET282 | 32; I-BET282 | Activity | = | 47.5 | nM | ALA4843841 | nM | Homo sapiens | |||
| 5. | I-BET282 | 32; I-BET282 | Activity | = | 1.73 | nM | ALA4843840 | nM | Homo sapiens | |||
| 6. | I-BET282 | 32; I-BET282 | deltaTm | = | 9.9 | degrees C | ALA4843839 | degrees C | Homo sapiens | |||
| 7. | I-BET282 | 32; I-BET282 | deltaTm | = | 3.4 | degrees C | ALA4843838 | degrees C | Homo sapiens | |||
| 8. | I-BET282 | 32; I-BET282 | Tmax | = | 0.75 | hr | ALA4843837 | hr | ||||
| 9. | I-BET282 | 32; I-BET282 | Tmax | = | 1 | hr | ALA4843836 | hr | ||||
| 10. | I-BET282 | 32; I-BET282 | Cmax | = | 177 | ng/ml | ALA4843835 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | |||
| 11. | I-BET282 | 32; I-BET282 | Cmax | = | 125 | ng/ml | ALA4843834 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | |||
| 12. | I-BET282 | 32; I-BET282 | AUCt | = | 367 | ng.hr/ml | ALA4843833 | ng.hr.mL-1 | ||||
| 13. | I-BET282 | 32; I-BET282 | AUCt | = | 467 | ng.hr/ml | ALA4843832 | ng.hr.mL-1 | ||||
| 14. | I-BET282 | 32; I-BET282 | F | = | 31 | % | ALA4843831 | % | ||||
| 15. | I-BET282 | 32; I-BET282 | F | = | 74 | % | ALA4843830 | % | ||||
| 16. | I-BET282 | 32; I-BET282 | F | = | 51 | % | ALA4843829 | % | ||||
| 17. | I-BET282 | 32; I-BET282 | t1/2 | = | 1.8 | hr | ALA4843828 | hr | ||||
| 18. | I-BET282 | 32; I-BET282 | t1/2 | = | 1.4 | hr | ALA4843827 | hr | ||||
| 19. | I-BET282 | 32; I-BET282 | t1/2 | = | 1.2 | hr | ALA4843826 | hr | ||||
| 20. | I-BET282 | 32; I-BET282 | Vdss | = | 3.1 | L/Kg | ALA4843825 | L.kg-1 |
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