# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA5074906 | 2 | Activity | 0 | ALA5050316 | Active | Trypanosoma congolense | |||||
2. | ALA5074906 | 2 | Cmax | = | 34 | ng/ml | ALA5050315 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | |||
3. | ALA5074906 | 2 | Activity | 0 | ALA5050314 | Not Active | Trypanosoma vivax | |||||
4. | ALA5074906 | 2 | Activity | 0 | ALA5050313 | Not Active | Trypanosoma vivax | |||||
5. | ALA5074906 | 2 | Activity | 0 | ALA5050312 | Not Active | Trypanosoma vivax | |||||
6. | ALA5074906 | 2 | Activity | 0 | ALA5050311 | Not Active | Trypanosoma congolense | |||||
7. | ALA5074906 | 2 | Activity | = | 100 | % | ALA5050309 | % | Trypanosoma vivax | |||
8. | ALA5074906 | 2 | Activity | = | 100 | % | ALA5050308 | % | Trypanosoma vivax | |||
9. | ALA5074906 | 2 | Activity | = | 100 | % | ALA5050307 | % | Trypanosoma vivax | |||
10. | ALA5074906 | 2 | Activity | = | 100 | % | ALA5050306 | % | Trypanosoma congolense | |||
11. | ALA5074906 | 2 | EC50 | = | 3600 | nM | ALA5050305 | 5.44 | nM | Rattus norvegicus | ||
12. | ALA5074906 | 2 | F | = | 73 | % | ALA5050304 | % | ||||
13. | ALA5074906 | 2 | AUC | = | 500000 | ng.min/ml | ALA5050303 | ng.hr.mL-1 | ||||
14. | ALA5074906 | 2 | AUC | = | 140000 | ng.min/ml | ALA5050300 | ng.hr.mL-1 | ||||
15. | ALA5074906 | 2 | t1/2 | = | 4 | hr | ALA5050298 | hr | ||||
16. | ALA5074906 | 2 | Vdss | = | 2.3 | L/Kg | ALA5050296 | L.kg-1 | ||||
17. | ALA5074906 | 2 | CL | = | 15 | ml/min.kg | ALA5050294 | mL.min-1.kg-1 | ||||
18. | ALA5074906 | 2 | CLH | = | 1.1 | ml/min/g | ALA5050281 | mL.min-1.g-1 | ||||
19. | ALA5074906 | 2 | EC50 | = | 0.08 | nM | ALA5050278 | 10.10 | nM | Trypanosoma vivax | ||
20. | ALA5074906 | 2 | EC50 | = | 3.2 | nM | ALA5050277 | 8.49 | nM | Trypanosoma congolense |