# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | mitiperstat | MITIPERSTAT | Selectivity ratio | = | 5 | ALA5130545 | ||||||
2. | mitiperstat | MITIPERSTAT | Cp | = | 1.7 | nM | ALA5130544 | nM | ||||
3. | mitiperstat | MITIPERSTAT | INH | 0 | ALA5130543 | Dde | % | |||||
4. | mitiperstat | MITIPERSTAT | Activity | 0 | ALA5130542 | Non-Toxic | ||||||
5. | mitiperstat | MITIPERSTAT | Activity | 0 | ALA5130541 | Non-Toxic | ||||||
6. | mitiperstat | MITIPERSTAT | NOAEL | = | 100 | mg/kg/day | ALA5130540 | mg/kg/day | ||||
7. | mitiperstat | MITIPERSTAT | NOAEL | = | 125 | mg/kg/day | ALA5130539 | mg/kg/day | ||||
8. | mitiperstat | MITIPERSTAT | NOAEL | = | 125 | mg/kg/day | ALA5130538 | mg/kg/day | ||||
9. | mitiperstat | MITIPERSTAT | Activity | 0 | ALA5130537 | Non-Toxic | Mus musculus | |||||
10. | mitiperstat | MITIPERSTAT | Activity | 0 | ALA5130536 | Non-Toxic | ||||||
11. | mitiperstat | MITIPERSTAT | Activity | 0 | ALA5130535 | Non-Toxic | ||||||
12. | mitiperstat | MITIPERSTAT | Activity | 0 | ALA5130534 | Non-Toxic | ||||||
13. | mitiperstat | MITIPERSTAT | Drug uptake | = | 56 | pmol | ALA5130529 | pmol | ||||
14. | mitiperstat | MITIPERSTAT | INH | 0 | ALA5130524 | NA | % | Homo sapiens | ||||
15. | mitiperstat | MITIPERSTAT | Fu | = | 0.7 | % | ALA5130523 | |||||
16. | mitiperstat | MITIPERSTAT | F | = | 52 | % | ALA5130522 | % | ||||
17. | mitiperstat | MITIPERSTAT | CL | = | 5.7 | ml/min.kg | ALA5130521 | mL.min-1.kg-1 | ||||
18. | mitiperstat | MITIPERSTAT | F | = | 61 | % | ALA5130520 | % | ||||
19. | mitiperstat | MITIPERSTAT | CL | = | 19 | ml/min.kg | ALA5130519 | mL.min-1.kg-1 | ||||
20. | mitiperstat | MITIPERSTAT | IC50 | = | 6 | uM | ALA5130518 | 5.22 | nM | Homo sapiens |