# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA5174953 | 4f | INH | = | 43 | % | ALA5167078 | % | Rattus norvegicus | |||
2. | ALA5174953 | 4f | Cmax | = | 0.03 | uM | ALA5167077 | nM | ||||
3. | ALA5174953 | 4f | Cmax | = | 6.36 | uM | ALA5167076 | nM | ||||
4. | ALA5174953 | 4f | Ct | = | 4.58 | uM | ALA5167075 | uM | ||||
5. | ALA5174953 | 4f | Ratio | > | 2.5 | ALA5167073 | ||||||
6. | ALA5174953 | 4f | Drug uptake | = | 5.4 | % | ALA5167072 | % | ||||
7. | ALA5174953 | 4f | Drug uptake | = | 10 | % | ALA5167070 | % | ||||
8. | ALA5174953 | 4f | Ratio | = | 183 | ALA5167069 | ||||||
9. | ALA5174953 | 4f | PB | = | 99.8 | % | ALA5167063 | % | ||||
10. | ALA5174953 | 4f | PPB | = | 99.6 | % | ALA5167062 | % | ||||
11. | ALA5174953 | 4f | permeability | = | 1.9 | 10^-6 cm/s | ALA5167060 | 10^-6 cm/s | ||||
12. | ALA5174953 | 4f | solubility | = | 0.62 | mg/ml | ALA5167059 | ug.mL-1 | ||||
13. | ALA5174953 | 4f | IC50 | > | 10000 | nM | ALA5167058 | nM | Homo sapiens | |||
14. | ALA5174953 | 4f | IC50 | = | 805 | nM | ALA5167057 | 6.09 | nM | Homo sapiens | ||
15. | ALA5174953 | 4f | IC50 | = | 0.1 | nM | ALA5167056 | 10.00 | nM | Homo sapiens | ||
16. | ALA5174953 | 4f | t1/2 | > | 16 | hr | ALA5167055 | hr | Homo sapiens | |||
17. | ALA5174953 | 4f | IC50 | = | 0.5 | nM | ALA5167054 | 9.30 | nM | |||
18. | ALA5174953 | 4f | IC50 | = | 0.05 | nM | ALA5167053 | 10.30 | nM | Homo sapiens | ||
19. | ALA5174953 | 4f | t1/2 | 0 | ALA5167052 | ND |