| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA5191481 | 43; TPT-001 | Activity | 0 | ALA5141826 | Non-Toxic | ||||||
| 2. | ALA5191481 | 43; TPT-001 | INH | 0 | ALA5141825 | NA | % | |||||
| 3. | ALA5191481 | 43; TPT-001 | INH | 0 | ALA5141824 | NA | % | |||||
| 4. | ALA5191481 | 43; TPT-001 | INH | 0 | ALA5141823 | NA | % | |||||
| 5. | ALA5191481 | 43; TPT-001 | INH | = | 40 | % | ALA5141822 | % | ||||
| 6. | ALA5191481 | 43; TPT-001 | AUC | = | 195 | hr.ng/ml | ALA5141821 | ng.hr.mL-1 | ||||
| 7. | ALA5191481 | 43; TPT-001 | AUC | = | 7452 | hr.ng/ml | ALA5141820 | ng.hr.mL-1 | ||||
| 8. | ALA5191481 | 43; TPT-001 | IC50 | = | 1.57 | uM | ALA5141819 | 5.80 | nM | |||
| 9. | ALA5191481 | 43; TPT-001 | CLH | < | 115 | ml/min.kg | ALA5141818 | mL.min-1.kg-1 | ||||
| 10. | ALA5191481 | 43; TPT-001 | t1/2 | = | 60 | min | ALA5141817 | hr | ||||
| 11. | ALA5191481 | 43; TPT-001 | t1/2 | > | 60 | min | ALA5141816 | hr | ||||
| 12. | ALA5191481 | 43; TPT-001 | Papp | = | 79.7 | 10^-6 cm/s | ALA5141815 | 10^-6 cm/s | ||||
| 13. | ALA5191481 | 43; TPT-001 | Papp | = | 3 | 10^-6 cm/s | ALA5141814 | 10^-6 cm/s | ||||
| 14. | ALA5191481 | 43; TPT-001 | PPB | = | 85 | % | ALA5141813 | % | ||||
| 15. | ALA5191481 | 43; TPT-001 | PPB | = | 80 | % | ALA5141812 | % | ||||
| 16. | ALA5191481 | 43; TPT-001 | CLH | = | 137 | ml/min.kg | ALA5141811 | mL.min-1.kg-1 | ||||
| 17. | ALA5191481 | 43; TPT-001 | solubility | = | 190.9 | uM | ALA5141810 | nM | ||||
| 18. | ALA5191481 | 43; TPT-001 | solubility | = | 186.4 | uM | ALA5141809 | nM | ||||
| 19. | ALA5191481 | 43; TPT-001 | solubility | = | 166 | uM | ALA5141808 | nM | ||||
| 20. | ALA5191481 | 43; TPT-001 | IC50 | = | 0.014 | uM | ALA5141807 | 7.85 | nM | Homo sapiens |
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