Activities

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Activities

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#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	SOS1 PROTAC 9d	9d	Activity		0		ALA5160209		Active		Homo sapiens
2.	SOS1 PROTAC 9d	9d	Activity		0		ALA5160208		NA		Homo sapiens
3.	SOS1 PROTAC 9d	9d	Activity		0		ALA5160207		Active
4.	SOS1 PROTAC 9d	9d	Activity		0		ALA5160206		Non-Toxic
5.	SOS1 PROTAC 9d	9d	Activity		0		ALA5160205		Non-Toxic
6.	SOS1 PROTAC 9d	9d	TGI	=	86.1	%	ALA5160204			%	Homo sapiens
7.	SOS1 PROTAC 9d	9d	TGI	=	72.5	%	ALA5160203			%	Homo sapiens
8.	SOS1 PROTAC 9d	9d	Activity		0		ALA5160202		Non-Toxic
9.	SOS1 PROTAC 9d	9d	Activity		0		ALA5160201		Non-Toxic
10.	SOS1 PROTAC 9d	9d	MRT	=	10.2	hr	ALA5160200			hr
11.	SOS1 PROTAC 9d	9d	AUC	=	4420	hr.ng/ml	ALA5160199			ng.hr.mL-1
12.	SOS1 PROTAC 9d	9d	AUClast	=	3895	hr.ng/ml	ALA5160198			ng.hr.mL-1
13.	SOS1 PROTAC 9d	9d	Cmax	=	1221	ng/ml	ALA5160197		standard_value was converted from ug.mL-1 to nM using the parent compound MW \| standard_value was converted from ug.mL-1 to nM using the parent compound MW \| standard_value was converted from ug.mL-1 to nM using the parent compound MW \| standard_value was converted from ug.mL-1 to nM using the parent compound MW \| standard_value was converted from ug.mL-1 to nM using the parent compound MW \| standard_value was converted from ug.mL-1 to nM using the parent compound MW	nM
14.	SOS1 PROTAC 9d	9d	Tmax	=	0.25	hr	ALA5160196			hr
15.	SOS1 PROTAC 9d	9d	t1/2	=	8.64	hr	ALA5160195			hr
16.	SOS1 PROTAC 9d	9d	Activity		0		ALA5160194		Active
17.	SOS1 PROTAC 9d	9d	IC50	=	72.3	nM	ALA5160193	7.14		nM
18.	SOS1 PROTAC 9d	9d	Activity		0		ALA5160192		Active
19.	SOS1 PROTAC 9d	9d	Activity		0		ALA5160191		Active
20.	SOS1 PROTAC 9d	9d	Activity		0		ALA5160189		Non-Toxic		Homo sapiens