| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA5206613 | 8o; CZw-124 | IC50 | = | 3.4 | uM | ALA5139873 | 5.47 | nM | Homo sapiens | ||
| 2. | ALA5206613 | 8o; CZw-124 | Activity | 0 | ALA5139872 | Non-Toxic | ||||||
| 3. | ALA5206613 | 8o; CZw-124 | TGI | = | 46 | % | ALA5139871 | % | Homo sapiens | |||
| 4. | ALA5206613 | 8o; CZw-124 | TGI | = | 54 | % | ALA5139870 | % | Homo sapiens | |||
| 5. | ALA5206613 | 8o; CZw-124 | TGI | = | 71 | % | ALA5139869 | % | Homo sapiens | |||
| 6. | ALA5206613 | 8o; CZw-124 | Activity | 0 | ALA5139868 | Non-Toxic | ||||||
| 7. | ALA5206613 | 8o; CZw-124 | Activity | 0 | ALA5139867 | Non-Toxic | ||||||
| 8. | ALA5206613 | 8o; CZw-124 | Activity | 0 | ALA5139866 | Toxic | ||||||
| 9. | ALA5206613 | 8o; CZw-124 | Activity | 0 | ALA5139865 | Toxic | ||||||
| 10. | ALA5206613 | 8o; CZw-124 | Vz | = | 10.65 | L/Kg | ALA5139864 | L.kg-1 | ||||
| 11. | ALA5206613 | 8o; CZw-124 | MRT | = | 2.14 | hr | ALA5139863 | hr | ||||
| 12. | ALA5206613 | 8o; CZw-124 | CL | = | 49.3 | ml/min.kg | ALA5139862 | mL.min-1.kg-1 | ||||
| 13. | ALA5206613 | 8o; CZw-124 | AUC | = | 1043 | hr.ng/ml | ALA5139861 | ng.hr.mL-1 | ||||
| 14. | ALA5206613 | 8o; CZw-124 | AUClast | = | 1020 | hr.ng/ml | ALA5139860 | ng.hr.mL-1 | ||||
| 15. | ALA5206613 | 8o; CZw-124 | Cmax | = | 861 | ng/ml | ALA5139859 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | |||
| 16. | ALA5206613 | 8o; CZw-124 | t1/2 | = | 2.71 | hr | ALA5139858 | hr | ||||
| 17. | ALA5206613 | 8o; CZw-124 | F | = | 8.63 | % | ALA5139857 | % | ||||
| 18. | ALA5206613 | 8o; CZw-124 | MRT | = | 12.3 | hr | ALA5139856 | hr | ||||
| 19. | ALA5206613 | 8o; CZw-124 | AUC | = | 273 | hr.ng/ml | ALA5139855 | ng.hr.mL-1 | ||||
| 20. | ALA5206613 | 8o; CZw-124 | AUClast | = | 184 | hr.ng/ml | ALA5139854 | ng.hr.mL-1 |
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