# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA5280373 | 31; EB-42486 | F | = | 40.1 | % | ALA5246770 | % | ||||
2. | ALA5280373 | 31; EB-42486 | CL | = | 38.1 | ml/min.kg | ALA5246769 | mL.min-1.kg-1 | ||||
3. | ALA5280373 | 31; EB-42486 | MRT | = | 2.89 | hr | ALA5246768 | hr | ||||
4. | ALA5280373 | 31; EB-42486 | MRT | = | 1.14 | hr | ALA5246767 | hr | ||||
5. | ALA5280373 | 31; EB-42486 | t1/2 | = | 1.85 | hr | ALA5246766 | hr | ||||
6. | ALA5280373 | 31; EB-42486 | t1/2 | = | 0.87 | hr | ALA5246765 | hr | ||||
7. | ALA5280373 | 31; EB-42486 | Tmax | = | 0.5 | hr | ALA5246764 | hr | ||||
8. | ALA5280373 | 31; EB-42486 | Cmax | = | 0.299 | uM | ALA5246763 | nM | ||||
9. | ALA5280373 | 31; EB-42486 | Cmax | = | 0.615 | uM | ALA5246762 | nM | ||||
10. | ALA5280373 | 31; EB-42486 | AUC | = | 0.847 | uM/hr | ALA5246761 | standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | ng.hr.mL-1 | |||
11. | ALA5280373 | 31; EB-42486 | AUC | = | 0.528 | uM/hr | ALA5246760 | standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | ng.hr.mL-1 | |||
12. | ALA5280373 | 31; EB-42486 | Ratio IC50 | = | 344 | ALA5246759 | ||||||
13. | ALA5280373 | 31; EB-42486 | IC50 | = | 11.4 | nM | ALA5246758 | 7.94 | nM | Homo sapiens | ||
14. | ALA5280373 | 31; EB-42486 | IC50 | = | 3924 | nM | ALA5246757 | 5.41 | nM | Homo sapiens | ||
15. | ALA5280373 | 31; EB-42486 | Ratio IC50 | = | 71 | ALA5246756 | ||||||
16. | ALA5280373 | 31; EB-42486 | IC50 | = | 1.7 | nM | ALA5246755 | 8.77 | nM | Homo sapiens | ||
17. | ALA5280373 | 31; EB-42486 | IC50 | = | 117 | nM | ALA5246754 | 6.93 | nM | Homo sapiens | ||
18. | ALA5280373 | 31; EB-42486 | Ratio IC50 | = | 837 | ALA5246753 | ||||||
19. | ALA5280373 | 31; EB-42486 | IC50 | = | 2.5 | nM | ALA5246752 | 8.60 | nM | Homo sapiens | ||
20. | ALA5280373 | 31; EB-42486 | IC50 | = | 2092 | nM | ALA5246751 | 5.68 | nM | Homo sapiens |