Activities

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Activities

Activities

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#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Assay	Assay Organism
1.	ALA186097	8w (table-3)	IC50	=	0.82	nM	ALA918439	9.09	nM	Rattus norvegicus
2.	ALA186097	8w (table-3)	Decrease in exit latency	=	14	%	ALA875991		%	Rattus norvegicus
3.	ALA186097	8w (table-3)	Occupancy	=	23	%	ALA830445		%	Rattus norvegicus
4.	ALA186097	8w (table-3)	Mean free plasma concentration	=	0.36	nM	ALA875177		nM
5.	ALA186097	8w (table-3)	Mean total plasma concentration	=	21.7	nM	ALA830184		nM
6.	ALA186097	8w (table-3)	Decrease in exit latency	=	0	%	ALA877549		%	Rattus norvegicus
7.	ALA186097	8w (table-3)	Occupancy	=	17	%	ALA830444		%	Rattus norvegicus
8.	ALA186097	8w (table-3)	Mean free plasma concentration	=	0.05	nM	ALA830181		nM
9.	ALA186097	8w (table-3)	Inhibition	=	47	%	ALA875580		%	Homo sapiens
10.	ALA186097	8w (table-3)	Inhibition	=	53	%	ALA830726		%	Homo sapiens
11.	ALA186097	8w (table-3)	Mean total plasma concentration	=	3.1	nM	ALA830183		nM
12.	ALA186097	8w (table-3)	Inhibition	=	49	%	ALA830720		%	Homo sapiens
13.	ALA186097	8w (table-3)	IC50	=	38.7	nM	ALA832962	7.41	nM	Rattus norvegicus
14.	ALA186097	8w (table-3)	Bioavailabiility	=	24	%	ALA838667		%
15.	ALA186097	8w (table-3)	T1/2	=	27.6	hr	ALA839156		hr
16.	ALA186097	8w (table-3)	Volume of distribution	=	1.67	l kg-1	ALA830175		L.kg-1
17.	ALA186097	8w (table-3)	Clearance	=	1.67	l hr-1 kg-1	ALA828355		mL.min-1.kg-1
18.	ALA186097	8w (table-3)	Decrease in exit latency	=	81	%	ALA875992		%	Rattus norvegicus
19.	ALA186097	8w (table-3)	Occupancy	=	59	%	ALA830446		%	Rattus norvegicus
20.	ALA186097	8w (table-3)	Mean free plasma concentration	=	1.02	nM	ALA830182		nM