| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  FK-788 | (R)-4: FK-788 | CC50 | > | 20 | uM | ALA4296191 | Median N= 2; Maxinhib 0.9 Pct | nM | Homo sapiens | ||
| 2. | FK-788 | (R)-4: FK-788 | HC10 | > | 20 | uM | ALA4296784 | Median N= 2; Maxinhib -0.4 Pct | uM | |||
| 3. | FK-788 | (R)-4: FK-788 | MIC | > | 20 | uM | ALA4296184 | Median N= 2; Maxinhib 10.0 Pct | nM | Staphylococcus aureus | ||
| 4. | FK-788 | (R)-4: FK-788 | MIC | > | 20 | uM | ALA4296802 | Median N= 2; Maxinhib 12.2 Pct | nM | Pseudomonas aeruginosa | ||
| 5. | FK-788 | (R)-4: FK-788 | MIC | > | 20 | uM | ALA4296188 | Median N= 2; Maxinhib 24.3 Pct | nM | Acinetobacter baumannii | ||
| 6. | FK-788 | (R)-4: FK-788 | MIC | > | 20 | uM | ALA4296187 | Median N= 2; Maxinhib 19.1 Pct | nM | Pseudomonas aeruginosa | ||
| 7. | FK-788 | (R)-4: FK-788 | MIC | > | 20 | uM | ALA4296186 | Median N= 2; Maxinhib 15.7 Pct | nM | Klebsiella pneumoniae | ||
| 8. | FK-788 | (R)-4: FK-788 | MIC | > | 20 | uM | ALA4296185 | Median N= 2; Maxinhib 9.4 Pct | nM | Escherichia coli | ||
| 9. | FK-788 | (R)-4: FK-788 | MIC | > | 20 | uM | ALA4296190 | Median N= 2; Maxinhib 12.6 Pct | nM | Cryptococcus neoformans | ||
| 10. | FK-788 | (R)-4: FK-788 | MIC | > | 20 | uM | ALA4296189 | Median N= 2; Maxinhib 3.0 Pct | nM | Candida albicans | ||
| 11. | FK-788 | (R)-4: FK-788 | BPR | = | 0.57 | ALA910355 | Homo sapiens | |||||
| 12. | FK-788 | (R)-4: FK-788 | AUC | = | 327 | pg.hr/ml | ALA870486 | ng.hr.mL-1 | Homo sapiens | |||
| 13. | FK-788 | (R)-4: FK-788 | CL | = | 38 | ml/min.kg | ALA871067 | mL.min-1.kg-1 | Rattus norvegicus | |||
| 14. | FK-788 | (R)-4: FK-788 | T1/2 | = | 1.8 | hr | ALA871065 | hr | Rattus norvegicus | |||
| 15. | FK-788 | (R)-4: FK-788 | F | = | 9.6 | % | ALA871068 | % | Rattus norvegicus | |||
| 16. | FK-788 | (R)-4: FK-788 | AUC | = | 601 | ng/ml/hr | ALA871096 | ng.hr.mL-1 | Rattus norvegicus | |||
| 17. | FK-788 | (R)-4: FK-788 | Cmax | = | 282 | ng/ml | ALA870494 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Rattus norvegicus | ||
| 18. | FK-788 | (R)-4: FK-788 | CL | = | 31.9 | ml/min.kg | ALA870493 | mL.min-1.kg-1 | Rattus norvegicus | |||
| 19. | FK-788 | (R)-4: FK-788 | IC50 | = | 18 | nM | ALA870490 | 7.75 | nM | Homo sapiens | ||
| 20. | FK-788 | (R)-4: FK-788 | IC50 | = | 1400 | nM | ALA870489 | 5.85 | nM | Rattus norvegicus |
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