# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA222077 | 34 | PPB | > | 99 | % | ALA910080 | % | Rattus norvegicus | |||
2. | ALA222077 | 34 | Cmin | = | 129 | ug ml-1 | ALA910079 | ug ml-1 | Rattus norvegicus | |||
3. | ALA222077 | 34 | IC50 | = | 7.2 | uM | ALA910078 | 5.14 | nM | Rattus norvegicus | ||
4. | ALA222077 | 34 | AUC | = | 3840 | ALA910077 | Rattus norvegicus | |||||
5. | ALA222077 | 34 | Cmax | = | 198 | mg/ml | ALA910076 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Rattus norvegicus | ||
6. | ALA222077 | 34 | Selectivity ratio | = | 540 | ALA910075 | ||||||
7. | ALA222077 | 34 | Selectivity ratio | = | 540 | ALA910074 | ||||||
8. | ALA222077 | 34 | Selectivity ratio | = | 1700 | ALA910073 | ||||||
9. | ALA222077 | 34 | Selectivity ratio | = | 2400 | ALA910072 | Homo sapiens | |||||
10. | ALA222077 | 34 | IC50 | = | 40 | nM | ALA908443 | 7.40 | nM | Bos taurus | ||
11. | ALA222077 | 34 | t1/2 | = | 6.9 | hr | ALA908442 | hr | Rattus norvegicus | |||
12. | ALA222077 | 34 | Vdss | = | 0.34 | L/Kg | ALA908441 | L.kg-1 | Rattus norvegicus | |||
13. | ALA222077 | 34 | Cp | = | 0.63 | ml/min.kg | ALA908440 | mL.min-1.kg-1 | Rattus norvegicus | |||
14. | ALA222077 | 34 | ED50 | = | 1 | mg kg-1 | ALA908439 | mg.kg-1 | Homo sapiens | |||
15. | ALA222077 | 34 | Selectivity ratio | = | 619 | ALA908438 | ||||||
16. | ALA222077 | 34 | Selectivity ratio | = | 394 | ALA908437 | ||||||
17. | ALA222077 | 34 | Selectivity ratio | = | 397 | ALA908436 | ||||||
18. | ALA222077 | 34 | IC50 | = | 0.84 | nM | ALA908435 | 9.08 | nM | Homo sapiens | ||
19. | ALA222077 | 34 | IC50 | = | 0.36 | nM | ALA1002947 | 9.44 | nM | Homo sapiens | ||
20. | ALA222077 | 34 | FC | = | 2400 | ALA1002958 |