| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  microcystin-LR | Microcystin-LR [4(E),6(Z)] | Activity | 0 | ALA2077691 | substrate [(+)] | Rattus norvegicus | |||||
| 2. | microcystin-LR | Microcystin-LR [4(E),6(Z)] | Activity | 0 | ALA2078419 | is not a substrate [(-)] | Rattus norvegicus | |||||
| 3. | microcystin-LR | Microcystin-LR [4(E),6(Z)] | Activity | 0 | ALA2075565 | is not a substrate [(-)] | Rattus norvegicus | |||||
| 4. | microcystin-LR | Microcystin-LR [4(E),6(Z)] | Activity | 0 | ALA2077192 | is not a substrate [(-)] | Homo sapiens | |||||
| 5. | microcystin-LR | Microcystin-LR [4(E),6(Z)] | Km | = | 20 | uM | ALA2075956 | substrate [Km=20uM] | nM | Homo sapiens | ||
| 6. | microcystin-LR | Microcystin-LR [4(E),6(Z)] | Km | = | 12.4 | uM | ALA2077898 | substrate [Km=12.4uM] | nM | Homo sapiens | ||
| 7. | microcystin-LR | Microcystin-LR [4(E),6(Z)] | Km | = | 12.4 | uM | ALA2076790 | substrate [Km=12.4uM] | nM | Homo sapiens | ||
| 8. | microcystin-LR | Microcystin-LR [4(E),6(Z)] | INH | 0 | ALA2038279 | Active | % | |||||
| 9. | microcystin-LR | Microcystin-LR [4(E),6(Z)] | INH | 0 | ALA4419654 | Active | % | |||||
| 10. | microcystin-LR | Microcystin-LR [4(E),6(Z)] | EC50 | = | 35 | uM | ALA4150033 | 4.46 | nM | Homo sapiens | ||
| 11. | microcystin-LR | Microcystin-LR [4(E),6(Z)] | EC50 | > | 35 | uM | ALA4150034 | nM | Homo sapiens | |||
| 12. | microcystin-LR | Microcystin-LR [4(E),6(Z)] | IC50 | = | 0.15 | nM | ALA5227887 | 9.82 | nM | |||
| 13. | microcystin-LR | Microcystin-LR [4(E),6(Z)] | IC50 | = | 0.1 | nM | ALA5227886 | 10.00 | nM | |||
| 14. | microcystin-LR | Microcystin-LR [4(E),6(Z)] | IC50 | = | 10 | nM | ALA5227885 | 8.00 | nM | |||
| 15. | microcystin-LR | Microcystin-LR [4(E),6(Z)] | IC50 | = | 1 | nM | ALA5227876 | 9.00 | nM | Homo sapiens | ||
| 16. | microcystin-LR | Microcystin-LR [4(E),6(Z)] | IC50 | = | 200 | nM | ALA5227875 | 6.70 | nM | |||
| 17. | microcystin-LR | Microcystin-LR [4(E),6(Z)] | Hepatotoxicity | 0 | ALA1697730 | DILI positive (test set) | ||||||
| 18. | microcystin-LR | Microcystin-LR [4(E),6(Z)] | Hepatotoxicity | 0 | ALA1697722 | AH: Evidence for animal hepatotoxicity but not tested in humans | ||||||
| 19. | microcystin-LR | Microcystin-LR [4(E),6(Z)] | Activity | 0 | ALA1045868 | Toxic | Rattus norvegicus | |||||
| 20. | microcystin-LR | Microcystin-LR [4(E),6(Z)] | LC50 | = | 0.27 | uM | ALA1045866 | nM | Rattus norvegicus |
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