| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA244521 | 26 | pKa_B1 | 9.91 | ALA3301362 | "B1 Functional Group: Piperidine; Ionisation Formula: A0B1 (Functional Group: the part of the molecule the pKa refers to; Ionisation formula: AxBy where 'A' refers to acidic centers within the molecule that are appreciably ionised at a pH <= 11 and 'x' equals 0, 1 or 2; and 'B' refers to basic centers within the molecule that are appreciably ionised at a pH >= 2 and 'y' equals 0, 1, 2 or 3)." | ||||||
| 2. | ALA244521 | 26 | LogD7.4 | 3.6 | ALA3301363 | |||||||
| 3. | ALA244521 | 26 | CLint | 29.51 | microL/min/1E6 cells | ALA3301371 | uL.min-1.(10^6cells)-1 | |||||
| 4. | ALA244521 | 26 | CLint | 12.88 | microL/min/mg | ALA3301370 | mL.min-1.g-1 | |||||
| 5. | ALA244521 | 26 | Solubility | 537 | uM | ALA3301364 | nM | |||||
| 6. | ALA244521 | 26 | Activity | > | 1 | uM | ALA896855 | uM | ||||
| 7. | ALA244521 | 26 | Activity | > | 1 | uM | ALA896854 | uM | Homo sapiens | |||
| 8. | ALA244521 | 26 | Activity | > | 1 | uM | ALA896852 | uM | Homo sapiens | |||
| 9. | ALA244521 | 26 | Activity | > | 1 | uM | ALA896853 | uM | Homo sapiens | |||
| 10. | ALA244521 | 26 | Activity | 0 | ALA896847 | Active | Mus musculus | |||||
| 11. | ALA244521 | 26 | Activity | = | -20 | % | ALA896851 | % | Rattus norvegicus | |||
| 12. | ALA244521 | 26 | Activity | = | -17 | % | ALA896850 | % | Mus musculus | |||
| 13. | ALA244521 | 26 | Drug uptake | = | 76 | % | ALA896849 | % | Mus musculus | |||
| 14. | ALA244521 | 26 | Cmax | = | 0.8 | uM | ALA896848 | nM | Mus musculus | |||
| 15. | ALA244521 | 26 | Activity | 0 | ALA896846 | Active | Mus musculus | |||||
| 16. | ALA244521 | 26 | Activity | 0 | ALA896845 | Active | Mus musculus | |||||
| 17. | ALA244521 | 26 | Kbapp | = | 14 | nM | ALA895700 | nM | Homo sapiens | |||
| 18. | ALA244521 | 26 | E/Emax | = | 15 | % | ALA895699 | % | Homo sapiens | |||
| 19. | ALA244521 | 26 | F | = | 69 | % | ALA896839 | % | Rattus norvegicus | |||
| 20. | ALA244521 | 26 | Cmax | = | 0.07 | mg/L | ALA896838 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Rattus norvegicus |
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