| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA393576 | 12a | Ki | = | 720 | nM | ALA901400 | 6.14 | nM | Homo sapiens | ||
| 2. | ALA393576 | 12a | Ratio | = | 3.4 | ALA901399 | Homo sapiens | |||||
| 3. | ALA393576 | 12a | Papp | = | 20 | nm/s | ALA901398 | nm/s | Homo sapiens | |||
| 4. | ALA393576 | 12a | Selectivity ratio | = | 100 | ALA901387 | ||||||
| 5. | ALA393576 | 12a | Intrinsic activity | = | 107 | % | ALA901386 | % | Homo sapiens | |||
| 6. | ALA393576 | 12a | EC50 | = | 79 | nM | ALA901386 | 7.10 | nM | Homo sapiens | ||
| 7. | ALA393576 | 12a | Ki | = | 0.71 | nM | ALA901379 | 9.15 | nM | Mus musculus | ||
| 8. | ALA393576 | 12a | BPR | = | 0.23 | ALA901342 | ||||||
| 9. | ALA393576 | 12a | Drug uptake | = | 53 | ng/g | ALA901341 | ng/g | Mus musculus | |||
| 10. | ALA393576 | 12a | F | = | 19.5 | % | ALA901340 | % | Mus musculus | |||
| 11. | ALA393576 | 12a | AUC | = | 1950 | ng/mL.hr | ALA901339 | ng.hr.mL-1 | Mus musculus | |||
| 12. | ALA393576 | 12a | Cmax | = | 552 | ng/ml | ALA901338 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Mus musculus | ||
| 13. | ALA393576 | 12a | Tmax | = | 2 | hr | ALA901337 | hr | Mus musculus | |||
| 14. | ALA393576 | 12a | BPR | = | 0.14 | ALA901336 | ||||||
| 15. | ALA393576 | 12a | Drug uptake | = | 63 | ng/g | ALA901335 | ng/g | Mus musculus | |||
| 16. | ALA393576 | 12a | t1/2 | = | 10 | hr | ALA901334 | hr | Mus musculus | |||
| 17. | ALA393576 | 12a | Vd | = | 13 | L/Kg | ALA901333 | L.kg-1 | Mus musculus | |||
| 18. | ALA393576 | 12a | CL | = | 15 | ml/min.Kg | ALA900292 | mL.min-1.kg-1 | Mus musculus | |||
| 19. | ALA393576 | 12a | Log D | = | 1.8 | ALA900288 | ||||||
| 20. | ALA393576 | 12a | IC50 | = | 21 | nM | ALA900286 | 7.68 | nM | Homo sapiens |
The page will load shortly, Thanks for your patience!