| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA761 | Naphazoline | pKa_B1 | 10.3 | ALA3301362 | "B1 Functional Group: 1H-imidazole, 4,5-dihydro-; Ionisation Formula: A0B1 (Functional Group: the part of the molecule the pKa refers to; Ionisation formula: AxBy where 'A' refers to acidic centers within the molecule that are appreciably ionised at a pH <= 11 and 'x' equals 0, 1 or 2; and 'B' refers to basic centers within the molecule that are appreciably ionised at a pH >= 2 and 'y' equals 0, 1, 2 or 3)." | ||||||
| 2. | ALA761 | Naphazoline | inhibition | = | 0.52 | % | ALA4513082 | % | Severe acute respiratory syndrome coronavirus 2 | |||
| 3. | ALA761 | Naphazoline | Inhibition | = | 12.64 | % | ALA4495582 | % | Severe acute respiratory syndrome coronavirus 2 | |||
| 4. | ALA761 | Naphazoline | pKi | = | 8.64 | ALA3590965 | 8.64 | nM | Homo sapiens | |||
| 5. | ALA761 | Naphazoline | pEC50 | = | 7.26 | ALA3591120 | 7.26 | nM | Homo sapiens | |||
| 6. | ALA761 | Naphazoline | Emax | = | 55 | % | ALA3591121 | % | Homo sapiens | |||
| 7. | ALA761 | Naphazoline | Emax | = | 102 | % | ALA3590965 | % | Homo sapiens | |||
| 8. | ALA761 | Naphazoline | pIC50 | < | 4.7 | ALA4651403 | No. Measurements = 1 | nM | Severe acute respiratory syndrome coronavirus 2 | |||
| 9. | ALA761 | Naphazoline | IC50 | > | 0 | M | ALA4651403 | No. Measurements = 1 | nM | Severe acute respiratory syndrome coronavirus 2 | ||
| 10. | ALA761 | Naphazoline | inhibition | = | 0.52 | % | ALA4513082 | % | Severe acute respiratory syndrome coronavirus 2 | |||
| 11. | ALA761 | Naphazoline | inhibition | = | -1.27 | % | ALA4808150 | % | Homo sapiens | |||
| 12. | ALA761 | Naphazoline | inhibition | = | -17.05 | % | ALA4808149 | % | Homo sapiens | |||
| 13. | ALA761 | Naphazoline | IC50 | > | 1000 | uM | ALA4017550 | nM | Homo sapiens | |||
| 14. | ALA761 | Naphazoline | Hit score | = | 0.002 | ALA4303810 | Severe acute respiratory syndrome coronavirus 2 | |||||
| 15. | ALA761 | Naphazoline | AC50 | = | 0.001 | uM | ALA5291729 | 9.22 | Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">") | nM | Homo sapiens | |
| 16. | ALA761 | Naphazoline | AC50 | = | 0.14 | uM | ALA5291734 | 6.85 | Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">") | nM | Homo sapiens | |
| 17. | ALA761 | Naphazoline | AC50 | = | 0.043 | uM | ALA5291735 | 7.37 | Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">") | nM | Homo sapiens | |
| 18. | ALA761 | Naphazoline | AC50 | > | 30 | uM | ALA5291887 | Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">") | nM | Homo sapiens | ||
| 19. | ALA761 | Naphazoline | AC50 | > | 30 | uM | ALA5291761 | Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">") | nM | Homo sapiens | ||
| 20. | ALA761 | Naphazoline | AC50 | > | 30 | uM | ALA5291759 | Summarised AC50 (mean value for measurements with a relation sign "="; largest value for measurements with relation sign ">") | nM | Homo sapiens |
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