| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA440405 | 17 | pKa_A1 | 5.2 | ALA3301375 | "A1 Functional Group: Acylsulphonamide; Ionisation Formula: A1B0 (Functional Group: the part of the molecule the pKa refers to; Ionisation formula: AxBy where 'A' refers to acidic centers within the molecule that are appreciably ionised at a pH <= 11 and 'x' equals 0, 1 or 2; and 'B' refers to basic centers within the molecule that are appreciably ionised at a pH >= 2 and 'y' equals 0, 1, 2 or 3)." | ||||||
| 2. | ALA440405 | 17 | LogD7.4 | 1.5 | ALA3301363 | |||||||
| 3. | ALA440405 | 17 | PPB | 98.7 | % | ALA3301365 | % | |||||
| 4. | ALA440405 | 17 | CLint | 14.3 | microL/min/1E6 cells | ALA3301371 | uL.min-1.(10^6cells)-1 | |||||
| 5. | ALA440405 | 17 | CLint | < | 3 | microL/min/mg | ALA3301370 | mL.min-1.g-1 | ||||
| 6. | ALA440405 | 17 | IC50 | = | 2.1 | uM | ALA928890 | 5.68 | nM | Oryctolagus cuniculus | ||
| 7. | ALA440405 | 17 | IC50 | = | 0.032 | uM | ALA928889 | 7.50 | nM | Homo sapiens | ||
| 8. | ALA440405 | 17 | IC50 | = | 0.072 | uM | ALA928888 | 7.14 | nM | Homo sapiens |
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