| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA1630 | amodiaquin (II) | IC50 | = | 11 | uM | ALA3268866 | 4.96 | nM | |||
| 2. | ALA1630 | amodiaquin (II) | IC50 | > | 10 | uM | ALA3223115 | nM | Plasmodium falciparum | |||
| 3. | ALA1630 | amodiaquin (II) | IC50 | = | 0.015 | uM | ALA3223114 | 7.82 | nM | Plasmodium falciparum | ||
| 4. | ALA1630 | amodiaquin (II) | Hepatotoxicity (mechanism) | 0 | ALA3137740 | Allergic, Dose-dependant, Reactive metabolite | ||||||
| 5. | ALA1630 | amodiaquin (II) | Hepatotoxicity (time to onset) | 0 | ALA3137739 | 1 week - 1 year | ||||||
| 6. | ALA1630 | amodiaquin (II) | Hepatotoxicity (comment) | 0 | ALA3137738 | |||||||
| 7. | ALA1630 | amodiaquin (II) | Hepatotoxicity (successful reintroduction) | 0 | ALA3137737 | yes | ||||||
| 8. | ALA1630 | amodiaquin (II) | Hepatotoxicity (animal toxicity known) | 0 | ALA3137736 | |||||||
| 9. | ALA1630 | amodiaquin (II) | Hepatotoxicity (benign tumour) | = | 0 | ALA3137735 | references out of a total of 20 | |||||
| 10. | ALA1630 | amodiaquin (II) | Hepatotoxicity (malignant tumour) | = | 0 | ALA3137734 | references out of a total of 20 | |||||
| 11. | ALA1630 | amodiaquin (II) | Hepatotoxicity (steatosis) | = | 0 | ALA3137733 | references out of a total of 20 | |||||
| 12. | ALA1630 | amodiaquin (II) | Hepatotoxicity (association with vascular disease) | = | 0 | ALA3137732 | references out of a total of 20 | |||||
| 13. | ALA1630 | amodiaquin (II) | Hepatotoxicity (granulomatous hepatitis) | = | 0 | ALA3137731 | references out of a total of 20 | |||||
| 14. | ALA1630 | amodiaquin (II) | Hepatotoxicity (cirrhosis) | = | 1 | ALA3137730 | references out of a total of 20 | |||||
| 15. | ALA1630 | amodiaquin (II) | Hepatotoxicity (chronic liver disease) | = | 0 | ALA3137729 | references out of a total of 20 | |||||
| 16. | ALA1630 | amodiaquin (II) | Hepatotoxicity (severe hepatitis) | = | 8 | ALA3137728 | references out of a total of 20 | |||||
| 17. | ALA1630 | amodiaquin (II) | Hepatotoxicity (choleostasis) | = | 4 | ALA3137727 | references out of a total of 20 | |||||
| 18. | ALA1630 | amodiaquin (II) | Hepatotoxicity (cytolytic) | = | 11 | ALA3137726 | references out of a total of 20 | |||||
| 19. | ALA1630 | amodiaquin (II) | Hepatotoxicity (acute) | = | 6.7 | % | ALA3137725 | % | ||||
| 20. | ALA1630 | amodiaquin (II) | Hepatotoxicity (acute) | = | 18 | ALA3137724 | references out of a total of 20 |
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