# | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | ALA1086621 | 4a, NP078585 | F | = | 21 | % | ALA1116642 | % | Rattus norvegicus | |||
2. | ALA1086621 | 4a, NP078585 | Vdss | = | 10204 | ml/kg | ALA1116641 | L.kg-1 | Rattus norvegicus | |||
3. | ALA1086621 | 4a, NP078585 | t1/2 | = | 4.5 | hr | ALA1116640 | hr | Rattus norvegicus | |||
4. | ALA1086621 | 4a, NP078585 | AUC | = | 1021 | ng.hr/ml | ALA1116639 | ng.hr.mL-1 | Rattus norvegicus | |||
5. | ALA1086621 | 4a, NP078585 | AUC | = | 753 | ng.hr/ml | ALA1116638 | ng.hr.mL-1 | Rattus norvegicus | |||
6. | ALA1086621 | 4a, NP078585 | Tmax | = | 1 | ng.hr/ml | ALA1116637 | ng.hr/ml | Rattus norvegicus | |||
7. | ALA1086621 | 4a, NP078585 | Cmax | = | 173 | ng/ml | ALA1116636 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Rattus norvegicus | ||
8. | ALA1086621 | 4a, NP078585 | CL | = | 2111 | ml/hr.kg | ALA1116635 | mL.min-1.kg-1 | Rattus norvegicus | |||
9. | ALA1086621 | 4a, NP078585 | Vdss | = | 11693 | ml/kg | ALA1116634 | L.kg-1 | Rattus norvegicus | |||
10. | ALA1086621 | 4a, NP078585 | t1/2 | = | 5 | hr | ALA1116633 | hr | Rattus norvegicus | |||
11. | ALA1086621 | 4a, NP078585 | AUC | = | 975 | ng.hr/ml | ALA1116632 | ng.hr.mL-1 | Rattus norvegicus | |||
12. | ALA1086621 | 4a, NP078585 | AUC | = | 725 | ng.hr/ml | ALA1116631 | ng.hr.mL-1 | Rattus norvegicus | |||
13. | ALA1086621 | 4a, NP078585 | Cmax | = | 462 | ng/ml | ALA1116630 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Rattus norvegicus | ||
14. | ALA1086621 | 4a, NP078585 | INH | = | 98.7 | % | ALA1116644 | % | Homo sapiens | |||
15. | ALA1086621 | 4a, NP078585 | Activity | 0 | ALA1116643 | Active | Rattus norvegicus | |||||
16. | ALA1086621 | 4a, NP078585 | Ratio IC50 | = | 12 | ALA1116629 | ||||||
17. | ALA1086621 | 4a, NP078585 | IC50 | = | 2.84 | uM | ALA1116628 | 5.55 | nM | |||
18. | ALA1086621 | 4a, NP078585 | IC50 | = | 0.11 | uM | ALA1104120 | 6.96 | nM | Rattus norvegicus |