Activities

#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile	34	Drug uptake	=	118	nM	ALA1121275			nM
2.	3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile	34	Activity		0		ALA1121281		Not Active		Homo sapiens
3.	3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile	34	Activity		0		ALA1121280		Not Active		Homo sapiens
4.	3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile	34	INH		0		ALA1121279		Not Active	%
5.	3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile	34	INH		0		ALA1121278		Active	%	Rattus norvegicus
6.	3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile	34	INH		0		ALA1121277		Active	%	Rattus norvegicus
7.	3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile	34	Activity		0		ALA1121276		Active		Rattus norvegicus
8.	3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile	34	Cp	=	3.5	uM	ALA1121274			uM	Rattus norvegicus
9.	3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile	34	Drug uptake	=	10.5	uM	ALA1121273			uM	Rattus norvegicus
10.	3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile	34	Drug uptake	=	200	nM	ALA1121272			nM
11.	3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile	34	Cp	=	3.2	uM	ALA1121271			uM	Rattus norvegicus
12.	3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile	34	Drug uptake	=	24	uM	ALA1121270			uM	Rattus norvegicus
13.	3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile	34	Ratio	=	1		ALA1121269
14.	3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile	34	Papp	=	20	10'-6 cm/s	ALA1121289			10'-6 cm/s
15.	3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile	34	Ratio	=	1.9		ALA1121288
16.	3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile	34	Papp	=	14	10'-6 cm/s	ALA1121287			10'-6 cm/s
17.	3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile	34	Ratio	=	2.9		ALA1121286
18.	3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile	34	PPB	=	97	%	ALA1121285			%	Rattus norvegicus
19.	3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile	34	Emax	=	29	%	ALA1121282			%	Homo sapiens
20.	3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile	34	EC50	=	4.9	uM	ALA1121284	5.31		nM	Homo sapiens

1.

3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile

34

Drug uptake

=

118

nM

ALA1121275

nM

2.

3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile

34

Activity

0

ALA1121281

Not Active

Homo sapiens

3.

3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile

34

Activity

0

ALA1121280

Not Active

Homo sapiens

4.

3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile

34

INH

0

ALA1121279

Not Active

%

5.

3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile

34

INH

0

ALA1121278

Active

%

Rattus norvegicus

6.

3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile

34

INH

0

ALA1121277

Active

%

Rattus norvegicus

7.

3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile

34

Activity

0

ALA1121276

Active

Rattus norvegicus

8.

3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile

34

Cp

=

3.5

uM

ALA1121274

uM

Rattus norvegicus

9.

3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile

34

Drug uptake

=

10.5

uM

ALA1121273

uM

Rattus norvegicus

10.

3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile

34

Drug uptake

=

200

nM

ALA1121272

nM

11.

3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile

34

Cp

=

3.2

uM

ALA1121271

uM

Rattus norvegicus

12.

3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile

34

Drug uptake

=

24

uM

ALA1121270

uM

Rattus norvegicus

13.

3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile

34

Ratio

=

1

ALA1121269

14.

3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile

34

Papp

=

20

10'-6 cm/s

ALA1121289

10'-6 cm/s

15.

3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile

34

Ratio

=

1.9

ALA1121288

16.

3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile

34

Papp

=

14

10'-6 cm/s

ALA1121287

10'-6 cm/s

17.

3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile

34

Ratio

=

2.9

ALA1121286

18.

3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile

34

PPB

=

97

%

ALA1121285

%

Rattus norvegicus

19.

3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile

34

Emax

=

29

%

ALA1121282

%

Homo sapiens

20.

3-[(5S)-5-(4-tert-butylphenoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]benzonitrile

34

EC50

=

4.9

uM

ALA1121284

5.31

nM

Homo sapiens