| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA1201770 | METHYLNALTREXONE BROMIDE | pKi | = | 8.1 | ALA4411118 | 8.10 | nM | Homo sapiens | |||
| 2. | ALA1201770 | METHYLNALTREXONE BROMIDE | pKi | = | 6.3 | ALA4411119 | 6.30 | nM | Homo sapiens | |||
| 3. | ALA1201770 | METHYLNALTREXONE BROMIDE | pKi | = | 7.7 | ALA4411120 | 7.70 | nM | Cavia porcellus | |||
| 4. | ALA1201770 | METHYLNALTREXONE BROMIDE | Intrinsic activity | = | 19 | % | ALA4411121 | % | Homo sapiens | |||
| 5. | ALA1201770 | METHYLNALTREXONE BROMIDE | t1/2 | > | 90 | min | ALA4411123 | hr | ||||
| 6. | ALA1201770 | METHYLNALTREXONE BROMIDE | t1/2 | > | 90 | min | ALA4411124 | hr | ||||
| 7. | ALA1201770 | METHYLNALTREXONE BROMIDE | t1/2 | > | 90 | min | ALA4411125 | hr | ||||
| 8. | ALA1201770 | METHYLNALTREXONE BROMIDE | Kp | = | 2 | 10'-6 cm/s | ALA4411126 | 10'-6 cm/s | ||||
| 9. | ALA1201770 | METHYLNALTREXONE BROMIDE | Cmax | = | 0.57 | ug ml-1 | ALA4411128 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | |||
| 10. | ALA1201770 | METHYLNALTREXONE BROMIDE | AUCt | = | 0.49 | microg.hr/mL | ALA4411131 | ng.hr.mL-1 | ||||
| 11. | ALA1201770 | METHYLNALTREXONE BROMIDE | t1/2 | = | 2.8 | hr | ALA4411134 | hr | ||||
| 12. | ALA1201770 | METHYLNALTREXONE BROMIDE | F | = | 2.6 | % | ALA4411136 | % | ||||
| 13. | ALA1201770 | METHYLNALTREXONE BROMIDE | ID50 | = | 67 | mg kg-1 | ALA4411138 | mg.kg-1 | Mus musculus | |||
| 14. | ALA1201770 | METHYLNALTREXONE BROMIDE | ID50 | = | 25 | mg kg-1 | ALA4411139 | mg.kg-1 | Mus musculus | |||
| 15. | ALA1201770 | METHYLNALTREXONE BROMIDE | F | < | 1 | % | ALA4411162 | % | ||||
| 16. | ALA1201770 | METHYLNALTREXONE BROMIDE | ED50 | 0 | ALA4310631 | Not Determined | Rattus norvegicus | |||||
| 17. | ALA1201770 | METHYLNALTREXONE BROMIDE | ED50 | = | 4.5 | mg kg-1 | ALA4310630 | mg.kg-1 | Rattus norvegicus | |||
| 18. | ALA1201770 | METHYLNALTREXONE BROMIDE | ED50 | = | 0.69 | mg kg-1 | ALA4310628 | mg.kg-1 | Mustela putorius furo | |||
| 19. | ALA1201770 | METHYLNALTREXONE BROMIDE | Ke | = | 1080 | nM | ALA4310626 | nM | Homo sapiens | |||
| 20. | ALA1201770 | METHYLNALTREXONE BROMIDE | Ke | = | 56 | nM | ALA4310625 | nM | Homo sapiens |
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