| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA1255794 | Aplaviroc, GW-873140 | logP | = | 3.8 | ALA2184882 | ||||||
| 2. | ALA1255794 | Aplaviroc, GW-873140 | Kd | = | 3 | nM | ALA2184878 | 8.52 | nM | Homo sapiens | ||
| 3. | ALA1255794 | Aplaviroc, GW-873140 | IC50 | = | 0.1 | nM | ALA2184886 | 10.00 | nM | Human immunodeficiency virus 1 | ||
| 4. | ALA1255794 | Aplaviroc, GW-873140 | F | = | 30 | % | ALA2184887 | % | Macaca mulatta | |||
| 5. | ALA1255794 | Aplaviroc, GW-873140 | DILI_Concern | 0 | ALA4029350 | Most-Dili-Concern | Homo sapiens | |||||
| 6. | ALA1255794 | Aplaviroc, GW-873140 | DILI_severity_class | = | 8 | ALA4029349 | Homo sapiens | |||||
| 7. | ALA1255794 | Aplaviroc, GW-873140 | IC50 | = | 0.4 | nM | ALA4148442 | 9.40 | nM | Mus musculus | ||
| 8. | ALA1255794 | Aplaviroc, GW-873140 | IC50 | = | 5.8 | nM | ALA5261111 | 8.24 | nM | |||
| 9. | ALA1255794 | Aplaviroc, GW-873140 | DILI positive/negative | = | 1 | ALA1909321 | Source: LTKB_BD dataset; Commonality: unique | |||||
| 10. | ALA1255794 | Aplaviroc, GW-873140 | LTKB_BD DILI severity score | 0 | ALA1909291 | "DILI severity category; not applicable, is only true for the label characterization but not for the DILI severity" | ||||||
| 11. | ALA1255794 | Aplaviroc, GW-873140 | Activity | 0 | ALA1261976 | Toxic | Rattus norvegicus | |||||
| 12. | ALA1255794 | Aplaviroc, GW-873140 | t1/2 | = | 3 | hr | ALA1261975 | hr | Homo sapiens | |||
| 13. | ALA1255794 | Aplaviroc, GW-873140 | AUC | = | 5840 | ng.hr/ml | ALA1261974 | ng.hr.mL-1 | Homo sapiens | |||
| 14. | ALA1255794 | Aplaviroc, GW-873140 | AUC | = | 6065 | ng.hr/ml | ALA1261973 | ng.hr.mL-1 | Homo sapiens | |||
| 15. | ALA1255794 | Aplaviroc, GW-873140 | AUC | = | 2006 | ng.hr/ml | ALA1261972 | ng.hr.mL-1 | Homo sapiens | |||
| 16. | ALA1255794 | Aplaviroc, GW-873140 | AUC | = | 3413 | ng.hr/ml | ALA1261971 | ng.hr.mL-1 | Homo sapiens | |||
| 17. | ALA1255794 | Aplaviroc, GW-873140 | AUC | = | 2101 | ng.hr/ml | ALA1261970 | ng.hr.mL-1 | Homo sapiens | |||
| 18. | ALA1255794 | Aplaviroc, GW-873140 | Activity | 0 | ALA1261969 | Non-toxic | Cercopithecidae | |||||
| 19. | ALA1255794 | Aplaviroc, GW-873140 | Activity | 0 | ALA1261968 | Toxic | Rattus norvegicus | |||||
| 20. | ALA1255794 | Aplaviroc, GW-873140 | FC | = | 1.66 | ALA1261967 | Human immunodeficiency virus 1 |
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