| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA1276882 | 36 | IC50 | = | 30 | nM | ALA2328121 | 7.52 | nM | Homo sapiens | ||
| 2. | ALA1276882 | 36 | Activity | 0 | ALA1286449 | Dose-dependent effect | Rattus norvegicus | |||||
| 3. | ALA1276882 | 36 | solubility | > | 50 | ug ml-1 | ALA1286455 | ug.mL-1 | ||||
| 4. | ALA1276882 | 36 | Activity | = | 93.2 | % | ALA1286466 | % | Rattus norvegicus | |||
| 5. | ALA1276882 | 36 | Ratio IC50 | = | 79 | ALA1286457 | ||||||
| 6. | ALA1276882 | 36 | ED50 | = | 78 | mg kg-1 | ALA1286449 | mg.kg-1 | Rattus norvegicus | |||
| 7. | ALA1276882 | 36 | INH | > | 60 | % | ALA1286469 | % | Homo sapiens | |||
| 8. | ALA1276882 | 36 | INH | > | 60 | % | ALA1286468 | % | ||||
| 9. | ALA1276882 | 36 | INH | > | 60 | % | ALA1286467 | % | Homo sapiens | |||
| 10. | ALA1276882 | 36 | F | = | 18.2 | % | ALA1286460 | % | Rattus norvegicus | |||
| 11. | ALA1276882 | 36 | Vdss | = | 3.3 | L/Kg | ALA1286465 | L.kg-1 | Rattus norvegicus | |||
| 12. | ALA1276882 | 36 | CL | = | 2.04 | L/hr.Kg | ALA1286461 | mL.min-1.kg-1 | Rattus norvegicus | |||
| 13. | ALA1276882 | 36 | t1/2 | = | 1.9 | hr | ALA1286463 | hr | Rattus norvegicus | |||
| 14. | ALA1276882 | 36 | t1/2 | = | 1.6 | hr | ALA1286462 | hr | Rattus norvegicus | |||
| 15. | ALA1276882 | 36 | IC50 | = | 1.5 | uM | ALA1286453 | 5.82 | nM | Homo sapiens | ||
| 16. | ALA1276882 | 36 | IC50 | = | 0.48 | uM | ALA1286451 | 6.32 | nM | Mus musculus | ||
| 17. | ALA1276882 | 36 | Cmax | = | 0.15 | ug ml-1 | ALA1286464 | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | standard_value was converted from ug.mL-1 to nM using the parent compound MW | nM | Rattus norvegicus | ||
| 18. | ALA1276882 | 36 | IC50 | = | 0.085 | uM | ALA1286450 | 7.07 | nM | Rattus norvegicus | ||
| 19. | ALA1276882 | 36 | IC50 | = | 0.019 | uM | ALA1286452 | 7.72 | nM | Homo sapiens | ||
| 20. | ALA1276882 | 36 | CL | <= | 98 | uL/min | ALA1286456 | uL/min |
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