| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA1289316 | 21, INCB-3344 | inhibition | = | -0.08 | % | ALA4513082 | % | Severe acute respiratory syndrome coronavirus 2 | |||
| 2. | ALA1289316 | 21, INCB-3344 | inhibition | = | -0.08 | % | ALA4513082 | % | Severe acute respiratory syndrome coronavirus 2 | |||
| 3. | ALA1289316 | 21, INCB-3344 | Inhibition | = | 4.5 | % | ALA4495582 | % | Severe acute respiratory syndrome coronavirus 2 | |||
| 4. | ALA1289316 | 21, INCB-3344 | AUC | = | 3888 | nM.hr | ALA1291505 | standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | ng.hr.mL-1 | Mus musculus | ||
| 5. | ALA1289316 | 21, INCB-3344 | Cmax | = | 961 | nM | ALA1291504 | nM | Mus musculus | |||
| 6. | ALA1289316 | 21, INCB-3344 | F | = | 47 | % | ALA1291503 | % | Mus musculus | |||
| 7. | ALA1289316 | 21, INCB-3344 | AUC | = | 2664 | nM.hr | ALA1291502 | standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | standard_value was converted from uM.hr to ug.hr.mL-1 using the parent compound MW | ng.hr.mL-1 | Mus musculus | ||
| 8. | ALA1289316 | 21, INCB-3344 | Cmax | = | 1886 | nM | ALA1291453 | nM | Mus musculus | |||
| 9. | ALA1289316 | 21, INCB-3344 | t1/2 | = | 1 | hr | ALA1291452 | hr | Mus musculus | |||
| 10. | ALA1289316 | 21, INCB-3344 | Vdss | = | 2.8 | L/hr | ALA1291451 | L/hr | Mus musculus | |||
| 11. | ALA1289316 | 21, INCB-3344 | CL | = | 5.1 | L/hr/kg | ALA1291450 | mL.min-1.kg-1 | Mus musculus | |||
| 12. | ALA1289316 | 21, INCB-3344 | IC50 | > | 3 | uM | ALA1291449 | nM | Mus musculus | |||
| 13. | ALA1289316 | 21, INCB-3344 | IC50 | > | 1 | uM | ALA1291448 | nM | Mus musculus | |||
| 14. | ALA1289316 | 21, INCB-3344 | IC50 | = | 16 | uM | ALA1291447 | 4.80 | nM | Macaca fascicularis | ||
| 15. | ALA1289316 | 21, INCB-3344 | IC50 | = | 7.3 | uM | ALA1291446 | 5.14 | nM | Rattus norvegicus | ||
| 16. | ALA1289316 | 21, INCB-3344 | IC50 | = | 13 | uM | ALA1291445 | 4.89 | nM | Homo sapiens | ||
| 17. | ALA1289316 | 21, INCB-3344 | PB | = | 15 | % | ALA1291444 | % | Mus musculus | |||
| 18. | ALA1289316 | 21, INCB-3344 | PB | = | 24 | % | ALA1291443 | % | Homo sapiens | |||
| 19. | ALA1289316 | 21, INCB-3344 | IC50 | = | 7.8 | nM | ALA1291442 | 8.11 | nM | Mus musculus | ||
| 20. | ALA1289316 | 21, INCB-3344 | IC50 | = | 3.8 | nM | ALA1291441 | 8.42 | nM | Homo sapiens |
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