Activities

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Activities

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#	Name	Compound Key	Action Type	Relation	Activity Value	Units	Assay ID	Assay Description	Comment	Assay	Assay Organism
1.	ALA4776512	2	INH		0		ALA4731492		Active	%	Mus musculus
2.	FM-381	FM-381	INH		0		ALA4731492		Active	%	Mus musculus
3.	ALA4776512	2	INH		0		ALA4731491		Active	%	Mus musculus
4.	FM-381	FM-381	INH		0		ALA4731491		Active	%	Mus musculus
5.	ALA4776512	2	IC50	=	563.7	nM	ALA4731487	6.25		nM	Mus musculus
6.	FM-381	FM-381	IC50	=	790.4	nM	ALA4731487	6.10		nM	Mus musculus
7.	racemic-tofacitinib	CP-690550	IC50	=	236.2	nM	ALA4731486	6.63		nM	Mus musculus
8.	ALA4776512	2	IC50	>	10	uM	ALA4731486			nM	Mus musculus
9.	FM-381	FM-381	IC50	=	764	nM	ALA4731486	6.12		nM	Mus musculus
10.	ALA3601120	50	INH		0		ALA3602082		Active	%	Mus musculus
11.	ALA3601115	45	INH		0		ALA3602082		Active	%	Mus musculus
12.	JAK3-IN-1	9	INH		0		ALA3602078		Active	%	Mus musculus
13.	ALA3601115	45	INH		0		ALA3602078		Active	%	Mus musculus
14.	ALA3601120	50	INH		0		ALA3602078		Active	%	Mus musculus
15.	2-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-4-N-(1-methylimidazol-4-yl)- 7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	19a	IC50	=	2	uM	ALA3117010	5.70		nM	Mus musculus
16.	2-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-4-N-(1-methylimidazol-4-yl)- 7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	19a	INH		0		ALA3117010		Dose-dependent effect	%	Mus musculus
17.	ALA3940537	16h	IC50	=	848	nM	ALA3868068	6.07		nM	Mus musculus
18.	ALA3941571	16e	IC50	=	5357	nM	ALA3868068	5.27		nM	Mus musculus
19.	ALA3922588	16d	IC50	=	3325	nM	ALA3868068	5.48		nM	Mus musculus
20.	ALA3948663	16b	IC50	=	10078	nM	ALA3868068	5.00		nM	Mus musculus