| # | Name | Compound Key | Action Type | Relation | Activity Value | Units | Assay ID | Assay Description | Comment | Assay | Assay Organism | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |  ALA5274954 | 35 | IC50 | = | 0.57 | uM | ALA5246684 | 6.24 | nM | Homo sapiens | ||
| 2. |  ALA5288931 | 28 | IC50 | = | 0.27 | uM | ALA5246684 | 6.57 | nM | Homo sapiens | ||
| 3. |  ALA5283628 | 21 | IC50 | = | 0.036 | uM | ALA5246684 | 7.44 | nM | Homo sapiens | ||
| 4. |  larotrectinib | LAROTRECTINIB | IC50 | = | 5 | nM | ALA5237480 | 8.30 | nM | Homo sapiens | ||
| 5. |  Lorlatinib | 8k, PF-06463922 | Ki | = | 46 | nM | ALA5213176 | 7.34 | nM | Homo sapiens | ||
| 6. |  LDC1267 | 7; LDC1267 | % of control | < | 10 | % | ALA5212943 | % | Homo sapiens | |||
| 7. |  BMS-777607 | 10, BMS-777607 | % of control | = | 0.1 | % | ALA5212889 | % | Homo sapiens | |||
| 8. |  ALA4530401 | EUB0000704 | IC50 | = | 120 | nM | ALA5213475 | 6.92 | nM | Homo sapiens | ||
| 9. |  GW2580 | K00591a, Diaminopyrimidine1 | Kd | < | 100 | nM | ALA5214844 | nM | Homo sapiens | |||
| 10. |  BI 99179 | 13, BI-99179 | % of control | = | 32 | % | ALA5213853 | % | Homo sapiens | |||
| 11. |  ALA4762646 | EUB0000341aCl | % of control | = | 0 | % | ALA5214374 | % | Homo sapiens | |||
| 12. |  ALA4542873 | 6i | IC50 | = | 8100 | nM | ALA5210458 | 5.09 | nM | Homo sapiens | ||
| 13. |  (4R)-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-2-(pyrimidin-5-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide | 6 | IC50 | = | 2.9 | nM | ALA5210450 | 8.54 | nM | Homo sapiens | ||
| 14. |  Selitrectinib (LOXO-195) | SELITRECTINIB | IC50 | = | 1.4 | nM | ALA5210347 | 8.85 | nM | Homo sapiens | ||
| 15. | Selitrectinib (LOXO-195) | SELITRECTINIB | IC50 | = | 2 | nM | ALA5210131 | 8.70 | nM | Homo sapiens | ||
| 16. | Selitrectinib (LOXO-195) | SELITRECTINIB | IC50 | < | 5 | nM | ALA5209932 | nM | Homo sapiens | |||
| 17. | Selitrectinib (LOXO-195) | SELITRECTINIB | IC50 | = | 2.4 | nM | ALA5164769 | 8.62 | nM | Homo sapiens | ||
| 18. | larotrectinib | LAROTRECTINIB | IC50 | = | 4.6 | nM | ALA5164769 | 8.34 | nM | Homo sapiens | ||
| 19. |  ALA5184321 | 7c | IC50 | = | 8.5 | nM | ALA5164769 | 8.07 | nM | Homo sapiens | ||
| 20. |  ALA5195469 | 7b | IC50 | = | 11 | nM | ALA5164769 | 7.96 | nM | Homo sapiens |
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